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http://hdl.handle.net/10261/224845
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dc.contributor.author | Marcos Jiménez, Ana | es_ES |
dc.contributor.author | Sánchez‐Alonso, Santiago | es_ES |
dc.contributor.author | Alcaraz‐Serna, Ana | es_ES |
dc.contributor.author | Esparcia-Pinedo, Laura | es_ES |
dc.contributor.author | López‐Sanz, Celia | es_ES |
dc.contributor.author | Sampedro-Nuñez, Miguel | es_ES |
dc.contributor.author | Mateu‐Albero, Tamara | es_ES |
dc.contributor.author | Sánchez‐Cerrillo, Ildefonso | es_ES |
dc.contributor.author | Martínez‐Fleta, Petra | es_ES |
dc.contributor.author | Gabrie, Ligia | es_ES |
dc.contributor.author | Campo Guerola, Luciana del | es_ES |
dc.contributor.author | Rodríguez-Frade, José Miguel | es_ES |
dc.contributor.author | Casasnovas, José María | es_ES |
dc.contributor.author | Reyburn, H. T. | es_ES |
dc.contributor.author | Valés-Gómez, Mar | es_ES |
dc.contributor.author | López Trascasa, Margarita | es_ES |
dc.contributor.author | Martín‐Gayo, Enrique | es_ES |
dc.contributor.author | Calzada, María José | es_ES |
dc.contributor.author | Castañeda, Santos | es_ES |
dc.contributor.author | Fuente, Hortensia de la | es_ES |
dc.contributor.author | González-Álvaro, Isidoro | es_ES |
dc.contributor.author | Sánchez‐Madrid, Francisco | es_ES |
dc.contributor.author | Muñoz‐Calleja, Cecilia | es_ES |
dc.contributor.author | Alfranca, Arántzazu | es_ES |
dc.date.accessioned | 2020-12-14T17:07:55Z | - |
dc.date.available | 2020-12-14T17:07:55Z | - |
dc.date.issued | 2020-11-30 | - |
dc.identifier.citation | European Journal of Immunology (2020) | es_ES |
dc.identifier.issn | 0014-2980 | - |
dc.identifier.uri | http://hdl.handle.net/10261/224845 | - |
dc.description.abstract | SARS‐CoV‐2 infection causes an abrupt response by the host immune system, which is largely responsible for the outcome of COVID‐19. We investigated whether the specific immune responses in the peripheral blood of 276 patients associated to severity and progression of COVID‐19. At admission, dramatic lymphopenia of T, B and NK cells associated to severity. Conversely, the proportion of B cells, plasmablasts, circulating follicular helper T cells (cTfh) and CD56‐CD16+ NK‐cells increased. Regarding humoral immunity, levels of IgM, IgA and IgG were unaffected, but when degrees of severity were considered, IgG was lower in severe patients. Compared to healthy donors, complement C3 and C4 protein levels were higher in mild and moderate, but not in severe patients, while the activation peptide of C5 (C5a) increased from the admission in every patient, regardless their severity. Moreover, total IgG, the IgG1 and IgG3 isotypes and C4 decreased from day 0 to day 10 in patients who were hospitalized for more than two weeks, but not in patients who were discharged earlier. Our study provides important clues to understand the immune response observed in COVID‐19 patients, associating severity with an imbalanced humoral response and identifying new targets for therapeutic intervention. | es_ES |
dc.description.sponsorship | The study was funded by grants SAF2017-82886-R to FS-M from the Ministerio de Economía y Competitividad, and from “La Caixa Banking Foundation” (HR17-00016) to FS-M. Grant PI018/01163 to CMC and grant PI19/00549 to AA were funded by Fondo de Investigaciones Sanitarias, Ministerio de Sanidad y Consumo, Spain. SAF2017-82886-R, PI018/01163 and PI19/00549 grants were also cofunded by European Regional Development Fund, ERDF/FEDER. This work has been funded by grants Fondo Supera COVID (CRUE-Banco de Santander) to FSM, and “Ayuda Covid 2019” from Comunidad de Madrid. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | John Wiley & Sons | es_ES |
dc.relation | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/SAF2017-82886-R | es_ES |
dc.relation | SAF2017-82886-R/AEI/10.13039/501100011033 | es_ES |
dc.rights | closedAccess | es_ES |
dc.subject | COVID-19 | es_ES |
dc.subject | SARS-CoV-2 | es_ES |
dc.subject | Immunity | es_ES |
dc.subject | Complement | es_ES |
dc.subject | Immunoglobulins | es_ES |
dc.title | Deregulated cellular circuits driving immunoglobulins and complement consumption associate with the severity of COVID‐19 patients | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1002/eji.202048858 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | https://doi.org/10.1002/eji.202048858 | es_ES |
dc.identifier.e-issn | 1521-4141 | - |
dc.contributor.funder | Ministerio de Ciencia, Innovación y Universidades (España) | es_ES |
dc.contributor.funder | Agencia Estatal de Investigación (España) | es_ES |
dc.contributor.funder | Fundación la Caixa | es_ES |
dc.contributor.funder | European Commission | es_ES |
dc.contributor.funder | Comunidad de Madrid | es_ES |
dc.relation.csic | Sí | es_ES |
oprm.item.hasRevision | no ko 0 false | * |
dc.identifier.funder | http://dx.doi.org/10.13039/100012818 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100011033 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.identifier.pmid | 33251605 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
Aparece en las colecciones: | (PTI Salud Global) Colección Especial COVID-19 (CNB) Artículos |
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