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dc.contributor.authorMarcos Jiménez, Anaes_ES
dc.contributor.authorSánchez‐Alonso, Santiagoes_ES
dc.contributor.authorAlcaraz‐Serna, Anaes_ES
dc.contributor.authorEsparcia-Pinedo, Lauraes_ES
dc.contributor.authorLópez‐Sanz, Celiaes_ES
dc.contributor.authorSampedro-Nuñez, Migueles_ES
dc.contributor.authorMateu‐Albero, Tamaraes_ES
dc.contributor.authorSánchez‐Cerrillo, Ildefonsoes_ES
dc.contributor.authorMartínez‐Fleta, Petraes_ES
dc.contributor.authorGabrie, Ligiaes_ES
dc.contributor.authorCampo Guerola, Luciana deles_ES
dc.contributor.authorRodríguez-Frade, José Migueles_ES
dc.contributor.authorCasasnovas, José Maríaes_ES
dc.contributor.authorReyburn, H. T.es_ES
dc.contributor.authorValés-Gómez, Mares_ES
dc.contributor.authorLópez Trascasa, Margaritaes_ES
dc.contributor.authorMartín‐Gayo, Enriquees_ES
dc.contributor.authorCalzada, María Josées_ES
dc.contributor.authorCastañeda, Santoses_ES
dc.contributor.authorFuente, Hortensia de laes_ES
dc.contributor.authorGonzález-Álvaro, Isidoroes_ES
dc.contributor.authorSánchez‐Madrid, Franciscoes_ES
dc.contributor.authorMuñoz‐Calleja, Ceciliaes_ES
dc.contributor.authorAlfranca, Arántzazues_ES
dc.date.accessioned2020-12-14T17:07:55Z-
dc.date.available2020-12-14T17:07:55Z-
dc.date.issued2020-11-30-
dc.identifier.citationEuropean Journal of Immunology (2020)es_ES
dc.identifier.issn0014-2980-
dc.identifier.urihttp://hdl.handle.net/10261/224845-
dc.description.abstractSARS‐CoV‐2 infection causes an abrupt response by the host immune system, which is largely responsible for the outcome of COVID‐19. We investigated whether the specific immune responses in the peripheral blood of 276 patients associated to severity and progression of COVID‐19. At admission, dramatic lymphopenia of T, B and NK cells associated to severity. Conversely, the proportion of B cells, plasmablasts, circulating follicular helper T cells (cTfh) and CD56‐CD16+ NK‐cells increased. Regarding humoral immunity, levels of IgM, IgA and IgG were unaffected, but when degrees of severity were considered, IgG was lower in severe patients. Compared to healthy donors, complement C3 and C4 protein levels were higher in mild and moderate, but not in severe patients, while the activation peptide of C5 (C5a) increased from the admission in every patient, regardless their severity. Moreover, total IgG, the IgG1 and IgG3 isotypes and C4 decreased from day 0 to day 10 in patients who were hospitalized for more than two weeks, but not in patients who were discharged earlier. Our study provides important clues to understand the immune response observed in COVID‐19 patients, associating severity with an imbalanced humoral response and identifying new targets for therapeutic intervention.es_ES
dc.description.sponsorshipThe study was funded by grants SAF2017-82886-R to FS-M from the Ministerio de Economía y Competitividad, and from “La Caixa Banking Foundation” (HR17-00016) to FS-M. Grant PI018/01163 to CMC and grant PI19/00549 to AA were funded by Fondo de Investigaciones Sanitarias, Ministerio de Sanidad y Consumo, Spain. SAF2017-82886-R, PI018/01163 and PI19/00549 grants were also cofunded by European Regional Development Fund, ERDF/FEDER. This work has been funded by grants Fondo Supera COVID (CRUE-Banco de Santander) to FSM, and “Ayuda Covid 2019” from Comunidad de Madrid.es_ES
dc.language.isoenges_ES
dc.publisherJohn Wiley & Sonses_ES
dc.relationinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/SAF2017-82886-Res_ES
dc.relationSAF2017-82886-R/AEI/10.13039/501100011033es_ES
dc.rightsclosedAccesses_ES
dc.subjectCOVID-19es_ES
dc.subjectSARS-CoV-2es_ES
dc.subjectImmunityes_ES
dc.subjectComplementes_ES
dc.subjectImmunoglobulinses_ES
dc.titleDeregulated cellular circuits driving immunoglobulins and complement consumption associate with the severity of COVID‐19 patientses_ES
dc.typeartículoes_ES
dc.identifier.doi10.1002/eji.202048858-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttps://doi.org/10.1002/eji.202048858es_ES
dc.identifier.e-issn1521-4141-
dc.contributor.funderMinisterio de Ciencia, Innovación y Universidades (España)es_ES
dc.contributor.funderAgencia Estatal de Investigación (España)es_ES
dc.contributor.funderFundación la Caixaes_ES
dc.contributor.funderEuropean Commissiones_ES
dc.contributor.funderComunidad de Madrides_ES
dc.relation.csices_ES
oprm.item.hasRevisionno ko 0 false*
dc.identifier.funderhttp://dx.doi.org/10.13039/100012818es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100011033es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000780es_ES
dc.identifier.pmid33251605-
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.openairetypeartículo-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
Aparece en las colecciones: (PTI Salud Global) Colección Especial COVID-19
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