English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/223976
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:

Title

Structuring hydrophobic domains in Poly(N-isopropylacrylamide-co-Methacrylic acid) hydrogels

AuthorsLópez-González, Mar; Melia Rodrigo, M.; Valiente, M.; Trabado, I.; Mendicuti, Francisco; Marcelo, Gema
Issue Date2020
PublisherElsevier
CitationEuropean Polymer Journal 131 (2020)
AbstractPoly(N-isopropylacrylamide-co-methacrylic acid) hydrogels were structured with hydrophobic compartments. To achieve that, N-isopropylacrylamide was copolymerized with methacrylic acid and a small percentage (~0.4 %mol) of (3,4-dihydroxy-5-nitrophenyl)methacrylamide (nitrocatechol monomer) in the presence of sodium dodecyl sulphate at a concentration below its CMC value. All the results support the structuring of poly(N-isopropylacrylamide-co-methacrylic acid) hydrogels with hydrophobic domains in water. These compartments were found to be rich in methacrylic acid and nitrocatechol units. Moreover, the structuring disappeared when hydrogels were swollen at pH 7.4. The structured hydrogel was capable of loading hydrophobic molecules (methyl-2-naphthoate and methyl-9-anthracenecarboxylate) as well as charged drugs (doxorubicin hydrochloride). This hydrogel permitted cell adhesion and growth as well as its detachment when the temperature fell below the LCST.
Publisher version (URL)http://dx.doi.org/10.1016/j.eurpolymj.2020.109695
URIhttp://hdl.handle.net/10261/223976
DOIhttp://dx.doi.org/10.1016/j.eurpolymj.2020.109695
Identifiersdoi: 10.1016/j.eurpolymj.2020.109695
issn: 0014-3057
Appears in Collections:(ICTP) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.