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Optomechanical detection of vibration modes of a single bacterium

AuthorsGil-Santos, Eduardo ; Ruz Martínez, José Jaime ; Malvar, Óscar ; Favero, Iván; Lemaître, Aristide; Kosaka, Priscila M. ; García-López, Sergio; Calleja, Montserrat ; Tamayo de Miguel, Francisco Javier
Issue Date13-Apr-2020
PublisherNature Publishing Group
CitationNature Nanotechnology 15: 469-474 (2020)
AbstractLow-frequency vibration modes of biological particles, such as proteins, viruses and bacteria, involve coherent collective vibrations at frequencies in the terahertz and gigahertz domains. These vibration modes carry information on their structure and mechanical properties, which are good indicators of their biological state. In this work, we harnessed a particular regime in the physics of coupled mechanical resonators to directly measure these low-frequency mechanical resonances of a single bacterium. We deposit the bacterium on the surface of an ultrahigh frequency optomechanical disk resonator in ambient conditions. The vibration modes of the disk and bacterium hybridize when their associated frequencies are similar. We developed a general theoretical framework to describe this coupling, which allows us to retrieve the eigenfrequencies and mechanical loss of the bacterium low-frequency vibration modes (quality factor). Additionally, we analysed the effect of hydration on these vibrational modes. This work demonstrates that ultrahigh frequency optomechanical resonators can be used for vibrational spectrometry with the unique capability to obtain information on single biological entities.
Publisher version (URL)http://dx.doi.org/10.1038/s41565-020-0672-y
Identifiersdoi: 10.1038/s41565-020-0672-y
e-issn: 1748-3395
issn: 1748-3387
Appears in Collections:(IMN-CNM) Artículos
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