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Prorocentroic Acid, a Neuroactive Super-Carbon-Chain Compound from the Dinoflagellate Prorocentrum hoffmannianum

AuthorsDomínguez, Humberto J.; Cabrera-García, David; Cuadrado, Cristina; Novelli, Antonello; Fernández-Sánchez, M. Teresa; Fernández, José J.; Hernández Daranas, Antonio
KeywordsProrocentroic acid
Prorocentrum hoffmannianum
Issue DateNov-2020
PublisherAmerican Chemical Society
CitationOrganic Letters: 1-6 (2020)
AbstractProrocentroic acid (PA) was isolated from the dinoflagellate Prorocentrum hoffmannianum. Relative configurations for its 35 asymmetric centers, were determined by analysis of NMR data including heteronuclear couplings and quantum mechanical calculations. PA was tested by using murine cortical neurons grown on microelectrode-arrays. Long term exposure to subtoxic concentrations induced a significant reorganization of neuronal signaling, mainly by changes in the bursting activity. The observed effects could be due to the activation of a plasticity process.
Publisher version (URL)https://doi.org/10.1021/acs.orglett.0c03437
Appears in Collections:(IPNA) Artículos
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