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dc.contributor.authorPalenzuela, Oswaldoes_ES
dc.contributor.authorPozo, R. deles_ES
dc.contributor.authorPiazzon de Haro, María Carlaes_ES
dc.contributor.authorIsern-Subich, M.es_ES
dc.contributor.authorCeulemans, S.es_ES
dc.contributor.authorCoutteau, P.es_ES
dc.contributor.authorSitjà-Bobadilla, Ariadnaes_ES
dc.date.accessioned2020-11-19T08:53:23Z-
dc.date.available2020-11-19T08:53:23Z-
dc.date.issued2020-02-27-
dc.identifier.citationDiseases of Aquatic Organisms 138: 111-120 (2020)es_ES
dc.identifier.issn0177-5103-
dc.identifier.urihttp://hdl.handle.net/10261/223162-
dc.description.abstractIn gilthead sea bream Sparus aurata, infection by Enteromyxum leei produces a cachectic syndrome with anorexia, weight loss, severe epaxial muscle atrophy and, eventually, death. Currently, there are neither vaccines nor effective prescription medicines to control this infection. Nutraceutical approaches are raising interest in the aquaculture industry, responding to the lack of therapeutic tools for the management of insidious chronic losses due to parasites. In this study, the effect of a commercially available health-promoting feed additive (SANACORE® GM) at 2 different doses was tested in comparison with a basal diet without the additive during a laboratory-controlled challenge with E. leei. Group performance and biometrical values were monitored, and an in-depth parasitological diagnosis, quantification of parasite loads and histopathological examination were carried out at the end of the trial. Supplemented diets mitigated the anorexia and growth arrestment observed in challenged fish fed the basal diet. This mitigation was maximum in the highest dose group, whose growth performance was not different from that of unchallenged controls. Treated groups also presented lower prevalence of infection and a lower parasite load, although the differences in the mean intensity of infection were not statistically significant. Although the decrease in parasite levels was similar with both doses of additive tested, the pathogeny of the infection was mostly suppressed with the higher dose, while only mitigated with the lower dose. The mechanisms involved in the effects obtained remain to be investigated, but the results point to a modulation of the immunopathological response to the infection.es_ES
dc.description.sponsorshipThis study was partially supported by the EU H2020 program and by the Spanish Ministry of Economy and Competitiveness through ParaFishControl (634429) and AGL-2013-48560-R research projects, respectively. This publication reflects the views of the authors only; the European Commission cannot be held responsible for any use which may be made of the information contained therein. M.C.P. was contracted under CSIC PIE project no. 201740E013es_ES
dc.language.isoenges_ES
dc.publisherInter Researches_ES
dc.relationinfo:eu-repo/grantAgreement/EC/H2020/634429es_ES
dc.relationMINECO/ICTI2013-2016/AGL2013-48560-Res_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rightsopenAccesses_ES
dc.subjectParasiteses_ES
dc.subjectAquaculturees_ES
dc.subjectEnteromyxum leeies_ES
dc.subjectFunctional feed additiveses_ES
dc.subjectTreatmentses_ES
dc.subjectSparus aurataes_ES
dc.subjectSANACOREes_ES
dc.subjectMyxozoaes_ES
dc.titleEffect of a functional feed additive on mitigation of experimentally induced gilthead sea bream Sparus aurata enteromyxosises_ES
dc.typeartículoes_ES
dc.identifier.doihttp://dx.doi.org/10.3354/dao03453-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttp://dx.doi.org/10.3354/dao03453es_ES
dc.identifier.e-issn1616-1580-
dc.rights.licensehttp://creativecommons.org/licenses/by-nc-sa/4.0/es_ES
dc.contributor.funderEuropean Commissiones_ES
dc.contributor.funderMinisterio de Economía y Competitividad (España)es_ES
dc.relation.csices_ES
oprm.item.hasRevisionno ko 0 false*
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000780es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003329es_ES
dc.contributor.orcidPiazzon de Haro, María Carla [0000-0002-4949-8984]es_ES
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