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Modulation of equol production via different dietary regimens in an artificial model of the human colon

AuthorsVázquez, Lucía; Flórez García, Ana Belén CSIC ORCID; Verbruggen, Sanne; Redruello, Begoña CSIC ORCID; Verhoeven, Jessica; Venema, Koen; Mayo Pérez, Baltasar CSIC ORCID
KeywordsSoy isoflavones
Intestinal model
Human faeces
Intestinal microbiota
Issue DateMar-2020
CitationJournal of Functional Foods 66: 103819 (2020)
AbstractIn order to find dietary conditions favouring endogenous equol biosynthesis, a pooled faecal homogenate from equol-producing women was used to inoculate the TIM-2 artificial model of the human proximal colon. The model was fuelled with control diets not supplemented (C) or supplemented (C-ISO) with isoflavones, and two isoflavone-containing diets rich in carbohydrate (CH-ISO) or protein (PR-ISO). Compared to the C-ISO control, the CH-ISO diet doubled the production of equol, while with the PR-ISO diet the production of equol in cultures decreased sharply. The CH-ISO diet was also associated with enhanced butyrate production. The numbers of most bacterial populations analysed did not significantly change along cultures with any of the diets. Surprisingly, counts for a gene involved in equol production (tdr) were reduced in all cultures, reflecting a reduction in the number of equol-producing bacteria. In conclusion, under the TIM-2 culture conditions established, the CH-ISO diet favoured the synthesis of equol.
Publisher version (URL)http://dx.doi.org/10.1016/j.jff.2020.103819
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