English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/222950
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:

Title

An overview on fecal branched short-chain fatty acids along human life and as related with body mass index: Associated dietary and anthropometric factors

AuthorsRios-Covián, David ; González, Sonia; Nogacka, Alicja; Arboleya, Silvia ; Salazar, Nuria ; Gueimonde Fernández, Miguel ; González de los Reyes-Gavilán, Clara
KeywordsShort-chain fatty acids
Branched short-chain fatty acids
Isovaleric acid
Isobutyric acid
BMI
Age
Diet
Issue Date27-May-2020
PublisherFrontiers Media
CitationFrontiers in Microbiology 11: 973 (2020)
AbstractShort-chain fatty acids (SCFA) are the main bacterial products of the catabolism of carbohydrates and proteins in the gut, and their role is essential in host–microbiota interactions. Acetic, propionic, and butyric acids are the major SCFA produced in the gut, and they have been extensively studied. In contrast, branched short-chain fatty acids (BCFA), mainly isovaleric and isobutyric acids, are produced in less amounts and their fecal levels in different human groups, intestinal microbial producing populations, and influence on health are insufficiently known. They have been proposed as markers of protein fermentation, which leads to the concomitant production of other fermentation products that can be harmful for the colon epithelium. In this context, the aim of this study was to shed light into the production of BCFA by the human intestinal microbiota, as related to age, body mass index (BMI), and diet. Fecal levels of the different SCFA were analyzed by gas chromatography in 232 healthy individuals with ages between 3 months and 95 years, and BMI in adults ranging from 19 to 54. Dietary assessments in adults were obtained through a food frequency questionnaire (FFQ). Molar proportions of BCFA in feces were strongly and positively related with aging. However, not a significant relationship was obtained between BCFA and BMI. A negative correlation was found between the consumption of dietary insoluble fiber and fecal levels of BCFA. More studies are needed for improving our understanding on the relationship of BCFA production profile with the intestinal microbiota composition and human health.
Publisher version (URL)http://dx.doi.org/10.3389/fmicb.2020.00973
URIhttp://hdl.handle.net/10261/222950
DOI10.3389/fmicb.2020.00973
ISSN1664-302X
Appears in Collections:(IPLA) Artículos
Files in This Item:
File Description SizeFormat 
Overview_fecal.pdf1,47 MBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.