Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/222715COMPARTIR / EXPORTAR:
 SHARE
 CORE
BASE
|
|
| Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
| Título: | A reference map of the human binary protein interactome |
Autor: | Luck, Katja; Kim, Dae-Kyum; Lambourne, Luke; Spirohn, Kerstin; Campos-Laborie, Francisco J.; De Las Rivas, Javier CSIC ORCID CVN ; Hill, David E.; Vidal, Marc; Roth, Frederick P.; Calderwood, Michael A. | Fecha de publicación: | 2020 | Editor: | Springer Nature | Citación: | Nature 580: 402-408 (2020) | Resumen: | Global insights into cellular organization and genome function require comprehensive understanding of the interactome networks that mediate genotype–phenotype relationships1,2. Here we present a human ‘all-by-all’ reference interactome map of human binary protein interactions, or ‘HuRI’. With approximately 53,000 protein–protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. The integration of HuRI with genome3, transcriptome4 and proteome5 data enables cellular function to be studied within most physiological or pathological cellular contexts. We demonstrate the utility of HuRI in identifying the specific subcellular roles of protein–protein interactions. Inferred tissue-specific networks reveal general principles for the formation of cellular context-specific functions and elucidate potential molecular mechanisms that might underlie tissue-specific phenotypes of Mendelian diseases. HuRI is a systematic proteome-wide reference that links genomic variation to phenotypic outcomes. | Descripción: | et al. | Versión del editor: | https://doi.org/10.1038/s41586-020-2188-x | URI: | http://hdl.handle.net/10261/222715 | DOI: | 10.1038/s41586-020-2188-x | E-ISSN: | 1476-4687 |
| Aparece en las colecciones: | (IBMCC) Artículos |
Ficheros en este ítem:
| Fichero | Descripción | Tamaño | Formato | |
|---|---|---|---|---|
| accesoRestringido.pdf | 59,24 kB | Adobe PDF |  Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
418
checked on 14-abr-2024
SCOPUSTM
Citations
567
checked on 18-abr-2024
WEB OF SCIENCETM
Citations
499
checked on 25-feb-2024
Page view(s)
146
checked on 19-abr-2024
Download(s)
48
checked on 19-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
Artículos relacionados:
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.