Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/222261
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Michalska, Patrycja | es_ES |
dc.contributor.author | Buendía Abaitua, Izaskun | es_ES |
dc.contributor.author | Duarte, Pablo | es_ES |
dc.contributor.author | Fernández-Mendívil, Cristina | es_ES |
dc.contributor.author | Negredo, Pilar | es_ES |
dc.contributor.author | Cuadrado, Antonio | es_ES |
dc.contributor.author | López, Manuela G. | es_ES |
dc.contributor.author | León, Rafael | es_ES |
dc.date.accessioned | 2020-11-04T12:03:27Z | - |
dc.date.available | 2020-11-04T12:03:27Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Pharmacological Research 152: 104597 (2020) | es_ES |
dc.identifier.issn | 1043-6618 | - |
dc.identifier.uri | http://hdl.handle.net/10261/222261 | - |
dc.description.abstract | Neuroinflammation is increasingly associated to the onset and progression of neurodegenerative diseases. Furthermore, several lines of evidence have demonstrated the capacity of aberrant protein aggregates to activate the immune response, accelerating the advance of the disease. Compound ITH12674 is a melatonin-sulforaphane hybrid designed to exert a dual drug-prodrug mechanism of action that combines potent NRF2 induction and free radical scavenger activity. ITH12674 also showed neuroprotective properties in oxidative stress related models, that were dependant on its NRF2 inducing properties. Given the high impact of neuroinflammation in the pathogenesis of neurodegeneration, we foresaw to study the anti-inflammatory properties of ITH12674. ITH12674 reduced inflammatory markers in glial cell cultures and hippocampal tissue after LPS administration. The anti-inflammatory effect was related to inhibition of TLR4 receptors due to a direct interaction with the TLR4/MD2 complex at the hydrophobic cavity of MD2. ITH12674 is endowed with anti-inflammatory properties, that are complementary to the NRF2 inducing activity and neuroprotective properties. Thus, ITH12674 could be of potential interest for the treatment of diseases with chronic neuroinflammation. | es_ES |
dc.description.sponsorship | This work was supported by grants from IS Carlos III co-financed by the European Regional Development’s funds (FEDER), Programa Miguel Servet II (CP16/00014) and research project (grant PI17/01700) to RL; Fundación La Caixa, CaixaImpulse program (grant CI17-00048) to RL; Comunidad Autónoma de Madrid (grant B2017/BMD-3827) and Spanish Ministry of Science, Innovation and Education (grant RTI2018-095793-B-I00) to MGL. P.M., P.D. and C.F.-M thanks MECD for FPU fellowships (13/0373716/03977 and 15/03269 respectively). I.B thanks MECD for Juan de la Cierva fellowship (FJCI-2016/28282). We would also like to thank “Fundación Teófilo Hernando” for its continued support. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.relation | B2017/BMD-3827/NRF24AD-CM | es_ES |
dc.relation | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-095793-B-I00 | es_ES |
dc.relation | RTI2018-095793-B-I00/AEI/10.13039/501100011033 | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/FJCI-2016/28282 | es_ES |
dc.rights | closedAccess | es_ES |
dc.subject | Neuroinflammation | es_ES |
dc.subject | Neurodegenerative diseases | es_ES |
dc.subject | MD2 antagonist | es_ES |
dc.subject | TLR4 inhibitor | es_ES |
dc.subject | Antiinflammatory properties | es_ES |
dc.subject | Multi-target | es_ES |
dc.title | Melatonin-sulforaphane hybrid ITH12674 attenuates glial response in vivo by blocking LPS binding to MD2 and receptor oligomerization | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1016/j.phrs.2019.104597 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | https://doi.org/10.1016/j.phrs.2019.104597 | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | es_ES |
dc.contributor.funder | Fundación la Caixa | es_ES |
dc.contributor.funder | Comunidad de Madrid | es_ES |
dc.contributor.funder | Agencia Estatal de Investigación (España) | es_ES |
dc.contributor.funder | Ministerio de Ciencia, Innovación y Universidades (España) | es_ES |
dc.contributor.funder | Ministerio de Educación, Cultura y Deporte (España) | es_ES |
dc.contributor.funder | Instituto Fundación Teófilo Hernando | es_ES |
dc.contributor.funder | European Commission | es_ES |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | es_ES |
dc.relation.csic | Sí | es_ES |
oprm.item.hasRevision | no ko 0 false | * |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004587 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003176 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/100012818 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100011033 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | artículo | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
Aparece en las colecciones: | (IIBM) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 59,24 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
12
checked on 21-abr-2024
WEB OF SCIENCETM
Citations
11
checked on 25-feb-2024
Page view(s)
127
checked on 23-abr-2024
Download(s)
57
checked on 23-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.