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Inflammation in Parkinson’s disease: Mechanisms and therapeutic implications

AuthorsPajares, Marta; Rojo, Ana I. CSIC ORCID; Manda, Gina; Boscá, Lisardo CSIC ORCID CVN; Cuadrado, Antonio CSIC ORCID
KeywordsParkinson’s disease
Immune system
Issue Date2020
PublisherMultidisciplinary Digital Publishing Institute
CitationCells 9(7): 1687 (2020)
AbstractParkinson’s disease (PD) is a common neurodegenerative disorder primarily characterized by the death of dopaminergic neurons that project from the substantia nigra pars compacta. Although the molecular bases for PD development are still little defined, extensive evidence from human samples and animal models support the involvement of inflammation in onset or progression. However, the exact trigger for this response remains unclear. Here, we provide a systematic review of the cellular mediators, i.e., microglia, astroglia and endothelial cells. We also discuss the genetic and transcriptional control of inflammation in PD and the immunomodulatory role of dopamine and reactive oxygen species. Finally, we summarize the preclinical and clinical approaches targeting neuroinflammation in PD.
DescriptionThis article belongs to the Special Issue Neuroinflammation in Neurodegenerative and Neurological Diseases.
Publisher version (URL)https://doi.org/10.3390/cells9071687
Appears in Collections:(IIBM) Artículos
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