English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/222202
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:


Repositioning microbial biotechnology against COVID‐19: the case of microbial production of flavonoids

AuthorsGoris, Tobias; Pérez-Valero, Álvaro; Martínez, Igor; Yi, Dong; Fernández-Calleja, Luis; San León, D.; Bornscheuer, Uwe T.; Magadán-Corpas, Patricia; Lombó, Felipe; Nogales, Juan CSIC ORCID
Issue Date13-Oct-2020
PublisherJohn Wiley & Sons
CitationMicrobial Biotechnology (2020)
AbstractCoronavirus‐related disease 2019 (COVID‐19) became a pandemic in February 2020, and worldwide researchers try to tackle the disease with approved drugs of all kinds, or to develop novel compounds inhibiting viral spreading. Flavonoids, already investigated as antivirals in general, also might bear activities specific for the viral agent causing COVID‐19, SARS‐CoV‐2. Microbial biotechnology and especially synthetic biology may help to produce flavonoids, which are exclusive plant secondary metabolites, at a larger scale or indeed to find novel pharmaceutically active flavonoids. Here, we review the state of the art in (i) antiviral activity of flavonoids specific for coronaviruses and (ii) results derived from computational studies, mostly docking studies mainly inhibiting specific coronaviral proteins such as the 3CL (main) protease, the spike protein or the RNA‐dependent RNA polymerase. In the end, we strive towards a synthetic biology pipeline making the fast and tailored production of valuable antiviral flavonoids possible by applying the last concepts of division of labour through co‐cultivation/microbial community approaches to the DBTL (Design, Build, Test, Learn) principle.
Publisher version (URL)https://doi.org/10.1111/1751-7915.13675
Appears in Collections:(CNB) Artículos
(VICYT) Colección Especial COVID-19
Files in This Item:
File Description SizeFormat 
Repositioning microbial biotechnology against COVID19_Goris.pdf1,32 MBAdobe PDFThumbnail
Show full item record
Review this work

Related articles:

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.