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Título

Interaction of E2 and NS3 synthetic peptides of GB virus C/hepatitis G virus with model lipid membranes

AutorRojo, Nuria; Gómara Elena, María José; Busquets, M. Antònia; Alsina, M. Asunción; Haro Villar, Isabel
Palabras claveGB virus C/Hepatitis G virus
Synthetic peptides
Differential scanning calorimetry
Fluorescence
Fecha de publicación12-mar-2003
EditorElsevier
CitaciónTalanta - the International Journal of Pure and Applied Analyt Chemistry 60: 395-404 (2003)
ResumenThe membrane-interacting properties of two potential epitopes of the GB virus C/Hepatitis G virus, located respectively at the regions (99–118) of the E2 structural protein and (440–460) of the NS3 non-structural protein were studied. Changes in the intrinsic fluorescence of Trp and Tyr residues after the addition of DPPC–LUV revealed that the peptide–membrane interaction was optimal above the gel–liquid crystalline transition temperature of the lipid. Differential scanning calorimetry studies showed that the E2 peptide incorporated into lipid bilayers perturbs the packing of lipids and affects their thermotropic properties. Moreover, the 20-mer structural peptide induced a slow leakage of vesicular contents at 55 °C.
Descripción10 pages, 5 figures, 2 tables.-- PMID: 18969061 [PubMed].-- Printed version published Jun 13, 2003.-- Presented at 10th International Symposium on Luminescence Spectrometry - Detection Techniques in Flowing Streams - Quality Assurance and Applied Analyis, Spain, Jun 4, 2002.-- Edited by Ana M. Garcia Campana.
Versión del editorhttp://dx.doi.org/10.1016/S0039-9140(03)00070-5
URIhttp://hdl.handle.net/10261/22095
DOI10.1016/S0039-9140(03)00070-5
ISSN0039-9140 (Print)
1873-3573 (Online)
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