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Title: | Interaction of E2 and NS3 synthetic peptides of GB virus C/hepatitis G virus with model lipid membranes |
Authors: | Rojo, Nuria; Gómara Elena, María José CSIC ORCID; Busquets, M. Antònia; Alsina, M. Asunción CSIC; Haro Villar, Isabel CSIC ORCID | Keywords: | GB virus C/Hepatitis G virus Synthetic peptides Differential scanning calorimetry Fluorescence |
Issue Date: | 12-Mar-2003 | Publisher: | Elsevier | Citation: | Talanta - the International Journal of Pure and Applied Analyt Chemistry 60: 395-404 (2003) | Abstract: | The membrane-interacting properties of two potential epitopes of the GB virus C/Hepatitis G virus, located respectively at the regions (99–118) of the E2 structural protein and (440–460) of the NS3 non-structural protein were studied. Changes in the intrinsic fluorescence of Trp and Tyr residues after the addition of DPPC–LUV revealed that the peptide–membrane interaction was optimal above the gel–liquid crystalline transition temperature of the lipid. Differential scanning calorimetry studies showed that the E2 peptide incorporated into lipid bilayers perturbs the packing of lipids and affects their thermotropic properties. Moreover, the 20-mer structural peptide induced a slow leakage of vesicular contents at 55 °C. | Description: | 10 pages, 5 figures, 2 tables.-- PMID: 18969061 [PubMed].-- Printed version published Jun 13, 2003.-- Presented at 10th International Symposium on Luminescence Spectrometry - Detection Techniques in Flowing Streams - Quality Assurance and Applied Analyis, Spain, Jun 4, 2002.-- Edited by Ana M. Garcia Campana. | Publisher version (URL): | http://dx.doi.org/10.1016/S0039-9140(03)00070-5 | URI: | http://hdl.handle.net/10261/22095 | DOI: | 10.1016/S0039-9140(03)00070-5 | ISSN: | 0039-9140 | E-ISSN: | 1873-3573 |
Appears in Collections: | (IQAC) Artículos |
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