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dc.contributor.authorAllaw, Mohamades_ES
dc.contributor.authorManca, Maria Letiziaes_ES
dc.contributor.authorCaddeo, Carlaes_ES
dc.contributor.authorRecio, Maria Carmenes_ES
dc.contributor.authorPérez-Brocal, Vicentees_ES
dc.contributor.authorMoya, Andréses_ES
dc.contributor.authorFernàndez-Busquets, Xavieres_ES
dc.contributor.authorManconi, Mariaes_ES
dc.date.accessioned2020-10-06T10:35:17Z-
dc.date.available2020-10-06T10:35:17Z-
dc.date.issued2020-
dc.identifier.citationColloids and Surfaces B: Biointerfaces 193: 111146 (2020)es_ES
dc.identifier.issn0927-7765-
dc.identifier.urihttp://hdl.handle.net/10261/220824-
dc.description.abstractGrape extract-loaded fibre-enriched vesicles, nutriosomes, were prepared by combining antioxidant extracts obtained from grape pomaces and a prebiotic, soluble fibre (Nutriose®FM06). The nutriosomes were small in size (from ∼140 to 260 nm), homogeneous (polydispersity index < 0.2) and highly negative (∼ −79 mV). The vesicles were highly stable during 12 months of storage at 25 °C. When diluted with warmed (37 °C) acidic medium (pH 1.2) of high ionic strength, the vesicles only displayed an increase of the mean diameter and a low release of the extract, which were dependent on Nutriose concentration. The formulations were highly biocompatible and able to protect intestinal cells (Caco-2) from oxidative stress damage. In vivo results underlined that the composition of mouse microbiota was not affected by the vesicular formulations. Overall results support the potential application of grape nutriosomes as an alternative strategy for the protection of the intestinal tract.es_ES
dc.description.sponsorshipThis research was carried out with the financial support of the European Union under the ENI CBC Mediterranean Sea Basin Programme, Reference number A_A.2.1_0035. This work was supported by grants from the Spanish Ministry of Economy and Competitiveness (project SAF2015-65878-R), Carlos III Institute of Health (project PIE14/00045), Generalitat Valenciana (project Prometeo/2018/A/133), Asociación Española contra el Cancer (project AECC 2017-1485), and co-financed by the European Regional Development Fund (ERDF). ISGlobal and IBEC are members of the CERCA Programme, Generalitat de Catalunya. We acknowledge support from the Spanish Ministry of Science, Innovation and Universities through the “Centro de Excelencia Severo Ochoa 2019-2023” Program (CEX2018-000806-S). This research is part of ISGlobal's Program on the Molecular Mechanisms of Malaria which is partially supported by the Fundación Ramón Areces.es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relationMINECO/ICTI2013-2016/SAF2015-65878-Res_ES
dc.relationMICIU/ICTI2017-2020/CEX2018-000806-Ses_ES
dc.relationCEX2018-000806-S/AEI/10.13039/501100011033es_ES
dc.relation.isversionofPostprintes_ES
dc.rightsembargoedAccesses_ES
dc.subjectGrape pomacees_ES
dc.subjectAntioxidant activityes_ES
dc.subjectPhospholipid vesicleses_ES
dc.subjectNutriosomeses_ES
dc.subjectPrebiotic activityes_ES
dc.subjectIn vivo studieses_ES
dc.subjectGut microbiotaes_ES
dc.subjectIntestinal cellses_ES
dc.titleAdvanced strategy to exploit wine-making waste by manufacturing antioxidant and prebiotic fibre-enriched vesicles for intestinal healthes_ES
dc.typeartículoes_ES
dc.identifier.doi10.1016/j.colsurfb.2020.111146-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttps://doi.org/10.1016/j.colsurfb.2020.111146es_ES
dc.embargo.terms2021-05-24es_ES
dc.contributor.funderEuropean Commissiones_ES
dc.contributor.funderMinisterio de Economía y Competitividad (España)es_ES
dc.contributor.funderGeneralitat Valencianaes_ES
dc.contributor.funderInstituto de Salud Carlos IIIes_ES
dc.contributor.funderGeneralitat de Catalunyaes_ES
dc.contributor.funderAsociación Española Contra el Cánceres_ES
dc.contributor.funderMinisterio de Ciencia, Innovación y Universidades (España)es_ES
dc.contributor.funderAgencia Estatal de Investigación (España)es_ES
dc.contributor.funderFundación Ramón Areceses_ES
dc.relation.csices_ES
oprm.item.hasRevisionno ko 0 false*
dc.identifier.funderhttp://dx.doi.org/10.13039/501100004587es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003329es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100011033es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000780es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/100008054es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003359es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100002809es_ES
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