English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/220824
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:

Title

Advanced strategy to exploit wine-making waste by manufacturing antioxidant and prebiotic fibre-enriched vesicles for intestinal health

AuthorsAllaw, Mohamad; Manca, Maria Letizia; Caddeo, Carla; Recio, Maria Carmen; Pérez-Brocal, Vicente; Moya, Andrés; Fernàndez-Busquets, Xavier; Manconi, Maria
KeywordsGrape pomace
Antioxidant activity
Phospholipid vesicles
Nutriosomes
Prebiotic activity
In vivo studies
Gut microbiota
Intestinal cells
Issue Date2020
PublisherElsevier
CitationColloids and Surfaces B: Biointerfaces 193: 111146 (2020)
AbstractGrape extract-loaded fibre-enriched vesicles, nutriosomes, were prepared by combining antioxidant extracts obtained from grape pomaces and a prebiotic, soluble fibre (Nutriose®FM06). The nutriosomes were small in size (from ∼140 to 260 nm), homogeneous (polydispersity index < 0.2) and highly negative (∼ −79 mV). The vesicles were highly stable during 12 months of storage at 25 °C. When diluted with warmed (37 °C) acidic medium (pH 1.2) of high ionic strength, the vesicles only displayed an increase of the mean diameter and a low release of the extract, which were dependent on Nutriose concentration. The formulations were highly biocompatible and able to protect intestinal cells (Caco-2) from oxidative stress damage. In vivo results underlined that the composition of mouse microbiota was not affected by the vesicular formulations. Overall results support the potential application of grape nutriosomes as an alternative strategy for the protection of the intestinal tract.
Publisher version (URL)https://doi.org/10.1016/j.colsurfb.2020.111146
URIhttp://hdl.handle.net/10261/220824
DOI10.1016/j.colsurfb.2020.111146
ISSN0927-7765
Appears in Collections:(I2SysBio) Artículos
Files in This Item:
File Description SizeFormat 
advanhealt.pdf Embargoed until May 24, 20211,26 MBAdobe PDFThumbnail
View/Open    Request a copy
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.