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Título

Effective N-methylation of nitroarenes with methanol catalyzed by a functionalized NHC-based iridium catalyst: a green approach to N-methyl amines

AutorGonzález-Lainez, Miguel CSIC; Jiménez, M. Victoria CSIC ORCID ; Passarelli, Vincenzo CSIC ORCID; Pérez-Torrente, Jesús J. CSIC ORCID
Fecha de publicación2020
EditorRoyal Society of Chemistry (UK)
CitaciónCatalysis Science and Technology 10(10): 3458-3467 (2020)
ResumenCompound [IrBr(CO)2(κC-tBuImCH2PyCH2OMe)] featuring a flexible pyridine/OMe functionalized NHC ligand κ1C coordinated efficiently catalyzes the selective N-monomethylation of nitroarenes using methanol as both the reducing agent and the C1 source. A range of functionalized nitroarenes including heterocyclic or sterically hindered derivatives have been efficiently converted to the corresponding N-monomethyl amines in good yields at low catalyst loadings using sub-stoichiometric amounts of Cs2CO3 as a base. Mechanistic investigations support a borrowing-hydrogen mechanism in which methanol acts as the hydrogen source and methylating agent. Further, the hydrogen transfer reduction of nitrobenzene to aniline under optimized reaction conditions should proceed through a direct mechanism involving nitrosobenzene and N-phenylhydroxylamine intermediates.
Versión del editorhttps://doi.org/10.1039/D0CY00707B
URIhttp://hdl.handle.net/10261/220555
DOI10.1039/D0CY00707B
ISSN2044-4753
E-ISSN2044-4761
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