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Título: | Association of porcine swine leukocyte antigen (SLA) haplotypes with B- and T-cell immune response to foot-and-mouth disease virus (FMDV) peptides |
Autor: | León, Patricia de CSIC ORCID; Cañas-Arranz, Rodrigo; Saez, Yago; Forner, Mar; Defaus, Sira; Cuadra, Dolores; Bustos, Maria José; Torres, Elisa; Andreu, David; Blanco Lavilla, Esther CSIC ORCID; Sobrino Castelló, Francisco CSIC ORCID; Hammer, Sabine E. | Palabras clave: | swine foot-and-mouth disease virus dendrimer peptide swine leukocyte antigen SLA polymorphism Adaptive immunity vaccine Protection |
Fecha de publicación: | 8-sep-2020 | Editor: | Multidisciplinary Digital Publishing Institute | Citación: | Vaccines 8(3): 513 (2020) | Resumen: | Dendrimer peptides are promising vaccine candidates against the foot-and-mouth disease virus (FMDV). Several B-cell epitope (B2T) dendrimers, harboring a major FMDV antigenic B-cell site in VP1 protein, are covalently linked to heterotypic T-cell epitopes from 3A and/or 3D proteins, and elicited consistent levels of neutralizing antibodies and IFN-γ-producing cells in pigs. To address the contribution of the highly polymorphic nature of the porcine MHC (SLA, swine leukocyte antigen) on the immunogenicity of B2T dendrimers, low-resolution (Lr) haplotyping was performed. We looked for possible correlations between particular Lr haplotypes with neutralizing antibody and T-cell responses induced by B2T peptides. In this study, 63 pigs immunized with B2T dendrimers and 10 non-immunized (control) animals are analyzed. The results reveal a robust significant correlation between SLA class-II Lr haplotypes and the T-cell response. Similar correlations of T-cell response with SLA class-I Lr haplotypes, and between B-cell antibody response and SLA class-I and SLA class-II Lr haplotypes, were only found when the sample was reduced to animals with Lr haplotypes represented more than once. These results support the contribution of SLA class-II restricted T-cells to the magnitude of the T-cell response and to the antibody response evoked by the B2T dendrimers, being of potential value for peptide vaccine design against FMDV. | Versión del editor: | https://doi.org/10.3390/vaccines8030513 | URI: | http://hdl.handle.net/10261/220272 | DOI: | 10.3390/vaccines8030513 | E-ISSN: | 2076-393X |
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SLA_haplotypes_B_T-cell_immune_FMDV_Peptides.pdf | 3,11 MB | Adobe PDF | Visualizar/Abrir |
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