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Title

Diet as moderator in the association of adiposity with inflammatory biomarkers among adolescents in the HELENA study

AuthorsArouca, Aline; Moreno, Luis A.; González-Gil, Esther; Marcos, Ascensión CSIC; Widhalm, Kurt; Molnar, Denes; Manios, Yannis; Gottrand, Frederic; Kafatos, Anthony; Kersting, Mathilde; Sjöström, Michael; Amaro-Gahete, Francisco José; Ferrari, Marika; Huybrechts, Inge; González Gross, Marcela; De Henauw, Stefaan; Michels, Nathalie
Issue Date2019
PublisherSpringer Nature
CitationEuropean Journal of Nutrition 5: 1947–1960 (2019)
Abstract[Aim]: Our aim is to demonstrate that a healthy diet might reduce the relation between adiposity and inflammation, whereas an unhealthy diet may increase the effect of adiposity on inflammatory biomarkers.
[Methods]: In 618 adolescents (13–17 years) of the European HELENA study, data were available on body composition, a set of inflammation markers, and food intake determined by a self-administered computerized 24-h recall. A 9-point Mediterranean diet score and an antioxidant-rich diet score were used as dietary parameters and tested as moderator. Total body fat was represented by the sum of six skinfold thicknesses and central adiposity by waist circumference. A set of inflammation-related biomarkers was used as outcome: a pro/anti-inflammatory interleukins ratio, TGFβ-1, C-reactive protein, TNF-α, 3 cell adhesion molecules, and 3 types of immune cells; gamma-glutamyltransferase (GGT) and homocysteine were used as cardiovascular disease risk biomarkers, and alanine transaminase (ALT) as liver dysfunction biomarker. Multiple linear regression analyses tested moderation by diet in the adiposity-inflammation association and were adjusted for age, sex, country, puberty, socioeconomic status.
[Results]: Both the Mediterranean and antioxidant-rich diet, and overall and central adiposity, were important in the moderation. Diet was a significant protective moderator in the effect of adiposity on the pro/anti-inflammatory interleukins ratio, TGFβ-1, GGT, and ALT.
[Conclusion]: In conclusion, in some cases, a diet rich in antioxidants and essential nutrients may attenuate the concentration of inflammatory biomarkers caused by adiposity, whereas a poor diet appears to contribute to the onset of early oxidative stress signs.
Publisher version (URL)https://doi.org/10.1007/s00394-018-1749-3
URIhttp://hdl.handle.net/10261/219794
DOIhttp://dx.doi.org/10.1007/s00394-018-1749-3
ISSN1436-6207
E-ISSN1436-6215
Appears in Collections:(ICTAN) Artículos
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