English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/219718
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:


Volume-Conducted Origin of the Field Potential at the Lateral Habenula

AuthorsBertone-Cueto, N.I.; Makarova, J.; Mosqueira, A.; García-Violini, D.; Sánchez-Peña, Ricardo S.; Herreras, Óscar ; Belluscio, M.; Piriz, Joaquin
Keywordslateral habenula
field potential
volume conduction
theta rhythm
Issue Date2020
PublisherFrontiers Media
CitationFrontiers in Systems Neuroscience 13 (2020)
AbstractField potentials (FPs) are easily reached signals that provide information about the brain’s processing. However, FP should be interpreted cautiously since their biophysical bases are complex. The lateral habenula (LHb) is a brain structure involved in the encoding of aversive motivational values. Previous work indicates that the activity of the LHb is relevant for hippocampal-dependent learning. Moreover, it has been proposed that the interaction of the LHb with the hippocampal network is evidenced by the synchronization of LHb and hippocampal FPs during theta rhythm. However, the origin of the habenular FP has not been analyzed. Hence, its validity as a measurement of LHb activity has not been proven. In this work, we used electrophysiological recordings in anesthetized rats and feed-forward modeling to investigate biophysical basis of the FP recorded in the LHb. Our results indicate that the FP in the LHb during theta rhythm is a volume-conducted signal from the hippocampus. This result highlight that FPs must be thoroughly analyzed before its biological interpretation and argues against the use of the habenular FP signal as a readout of the activity of the LHb.
Publisher version (URL)http://dx.doi.org/10.3389/fnsys.2019.00078
Identifiersdoi: 10.3389/fnsys.2019.00078
issn: 1662-5137
Appears in Collections:(IC) Artículos
Files in This Item:
File Description SizeFormat 
fnsys-13-00078.pdf10,26 MBAdobe PDFThumbnail
Show full item record
Review this work

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.