English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/219669
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:


Factors regulating microRNA expression and function in multiple myeloma

AuthorsMisiewicz-Krzeminska, Irena; Krzemiński, Patryk; Corchete, Luis A.; Quwaider, Dalia; Rojas, Elizabeta A.; Herrero, Ana B.; Gutiérrez, Norma Carmen
Myeloma multiple
miRNA regulation
Issue Date2019
PublisherMultidisciplinary Digital Publishing Institute
CitationNon-Coding RNA 5(1): 9 (2019)
AbstractIntensive research has been undertaken during the last decade to identify the implication of microRNAs (miRNAs) in the pathogenesis of multiple myeloma (MM). The expression profiling of miRNAs in MM has provided relevant information, demonstrating different patterns of miRNA expression depending on the genetic abnormalities of MM and a key role of some miRNAs regulating critical genes associated with MM pathogenesis. However, the underlying causes of abnormal expression of miRNAs in myeloma cells remain mainly elusive. The final expression of the mature miRNAs is subject to multiple regulation mechanisms, such as copy number alterations, CpG methylation or transcription factors, together with impairment in miRNA biogenesis and differences in availability of the mRNA target sequence. In this review, we summarize the available knowledge about the factors involved in the regulation of miRNA expression and functionality in MM.
DescriptionThis article belongs to the Special Issue Non-Coding RNA in Multiple Myeloma.
Publisher version (URL)https://doi.org/10.3390/ncrna5010009
Appears in Collections:(IBMCC) Artículos
Files in This Item:
File Description SizeFormat 
factomyel.pdf2,17 MBAdobe PDFThumbnail
Show full item record
Review this work

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.