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Title

Factors regulating microRNA expression and function in multiple myeloma

AuthorsMisiewicz-Krzeminska, Irena; Krzemiński, Patryk; Corchete, Luis A.; Quwaider, Dalia; Rojas, Elizabeta A.; Herrero, Ana B.; Gutiérrez, Norma Carmen
KeywordsmiRNA
Methylation
Myeloma multiple
miRNA regulation
Issue Date2019
PublisherMultidisciplinary Digital Publishing Institute
CitationNon-Coding RNA 5(1): 9 (2019)
AbstractIntensive research has been undertaken during the last decade to identify the implication of microRNAs (miRNAs) in the pathogenesis of multiple myeloma (MM). The expression profiling of miRNAs in MM has provided relevant information, demonstrating different patterns of miRNA expression depending on the genetic abnormalities of MM and a key role of some miRNAs regulating critical genes associated with MM pathogenesis. However, the underlying causes of abnormal expression of miRNAs in myeloma cells remain mainly elusive. The final expression of the mature miRNAs is subject to multiple regulation mechanisms, such as copy number alterations, CpG methylation or transcription factors, together with impairment in miRNA biogenesis and differences in availability of the mRNA target sequence. In this review, we summarize the available knowledge about the factors involved in the regulation of miRNA expression and functionality in MM.
DescriptionThis article belongs to the Special Issue Non-Coding RNA in Multiple Myeloma.
Publisher version (URL)https://doi.org/10.3390/ncrna5010009
URIhttp://hdl.handle.net/10261/219669
DOIhttp://dx.doi.org/10.3390/ncrna5010009
E-ISSN2311-553X
Appears in Collections:(IBMCC) Artículos
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