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Título: | Evaluation of Anti-Inflammatory and Atheroprotective Properties of Wheat Gluten Protein Hydrolysates in Primary Human Monocytes |
Autor: | Montserrat-de la Paz, Sergio CSIC ORCID; Rodríguez-Martín, Noelia M. CSIC ORCID CVN; Villanueva, Álvaro CSIC ORCID ; Pedroche, Justo CSIC ORCID ; Cruz-Chamorro, Iván CSIC ORCID; Millán, Francisco CSIC ORCID ; Millán-Linares, María del Carmen CSIC ORCID | Palabras clave: | Wheat gluten Protein hydrolysates Atherosclerosis Monocytes Celiac disease |
Fecha de publicación: | 30-jun-2020 | Editor: | Multidisciplinary Digital Publishing Institute | Citación: | Foods 9 (7): 854 (2020) | Resumen: | Bioactive protein hydrolysates have been identified in several sources as possible agents in the prevention and treatment of many diseases. A wheat gluten (WG) concentrate was hydrolyzed by Alcalase under specific conditions. The resulting hydrolysates were evaluated by in vitro cell-free experiments leading to the identification of one bioactive WG protein hydrolysate (WGPH), which was used at 50 and 100 μg/mL on primary human monocytes. Reactive oxygen species (ROS) and nitrite levels and RT-qPCR and ELISA techniques were used to analyze the functional activity of WGPH. Our results showed that WGPH hydrolyzed in 45 min (WGPH45A) down-regulated gene expression of Interleukin (IL)-1β, IL-6, IL-17, and Interferon gamma (IFNγ) and reduced cytokine release in lipopolysaccharide (LPS)-stimulated monocytes. In addition, WGPH45A down-regulated gene-related to atherosclerotic onset. Our results suggest that WGPH45A has a potent anti-inflammatory and atheroprotective properties, reducing the expression of gene-related inflammation and atherosclerosis that could be instrumental in maintaining cardiovascular homeostasis. | Descripción: | 16 Páginas.-- 8 Figuras.-- 2 Tablas | Versión del editor: | http://dx.doi.org/10.3390/foods9070854 | URI: | http://hdl.handle.net/10261/219432 | E-ISSN: | 2304-8158 |
Aparece en las colecciones: | (IG) Artículos (IBIS) Artículos |
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