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Title

Prothoracicotropic hormone modulates environmental adaptive plasticity through the control of developmental timing

AuthorsShimell, M.J.; Pan, X.; Martín, Francisco A.; Ghosh, A.C.; Leopold, P.; O’Connor, M.B; Romero, N.M
KeywordsDrosophila development
Ecdysone
PTTH
Plasticity
Environmental cue
Issue Date2018
PublisherCompany of Biologists
CitationDevelopment 145 (2018)
AbstractAdult size and fitness are controlled by a combination of genetics and environmental cues. In Drosophila, growth is confined to the larval phase and final body size is impacted by the duration of this phase, which is under neuroendocrine control. The neuropeptide prothoracicotropic hormone (PTTH) has been proposed to play a central role in controlling the length of the larval phase through regulation of ecdysone production, a steroid hormone that initiates larval molting and metamorphosis. Here, we test this by examining the consequences of null mutations in the Ptth gene for Drosophila development. Loss of Ptth causes several developmental defects, including a delay in developmental timing, increase in critical weight, loss of coordination between body and imaginal disc growth, and reduced adult survival in suboptimal environmental conditions such as nutritional deprivation or high population density. These defects are caused by a decrease in ecdysone production associated with altered transcription of ecdysone biosynthetic genes. Therefore, the PTTH signal contributes to coordination between environmental cues and the developmental program to ensure individual fitness and survival.
Publisher version (URL)http://dx.doi.org/10.1242/dev.159699
URIhttp://hdl.handle.net/10261/219360
DOIhttp://dx.doi.org/10.1242/dev.159699
Identifiersdoi: 10.1242/dev.159699
issn: 1477-9129
Appears in Collections:(IC) Artículos
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