English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/219344
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:


Cocoa flavanols protect human endothelial cells from oxidative stress

AuthorsFerreira Martins, Tatiane; Palomino, Olga; Álvarez-Cilleros, David; Martín, M. Ángeles ; Ramos, Sonia ; Goya, Luis
Issue Date2020
PublisherSpringer Nature
CitationPlant Foods for Human Nutrition 75: 161–168 (2020)
AbstractOxidative stress may cause functional disorders of vascular endothelia which can lead to endothelial apoptosis and thus alter the function and structure of the vascular tissues. Plant antioxidants protect the endothelium against oxidative stress and then become an effective option to treat vascular diseases. Cocoa flavanols have been proven to protect against oxidative stress in cell culture and animal models. In addition, epidemiological and interventional studies strongly suggest that cocoa consumption has numerous beneficial effects on cardiovascular health. The objective of this study was to test the chemo-protective effect of realistic concentrations of a cocoa phenolic extract and its main monomeric flavanol epicatechin on cultured human endothelial cells submitted to an oxidative challenge. Both products efficiently restrained stress-induced reactive oxygen species and biomarkers of oxidative stress such as carbonyl groups and malondialdehyde, and recovered depleted glutathione, antioxidant defences and cell viability. Our results demonstrate for the first time that a polyphenolic extract from cocoa and its main flavonoid protect human endothelial cells against an oxidative insult by modulating oxygen radical generation and antioxidant enzyme and non-enzyme defences.
Publisher version (URL)https://doi.org/10.1007/s11130-020-00807-1
Appears in Collections:(ICTAN) Artículos
Files in This Item:
File Description SizeFormat 
Cocoa Flavanols Protect Human Endothelial Cells from Oxidative Stress.pdf3,61 MBAdobe PDFThumbnail
Show full item record
Review this work

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.