English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/219333
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:

Title

Association of UCP1, UCP2 and UCP3 gene polymorphisms with cardiovascular disease risk factors in European adolescents: the HELENA study

AuthorsPascual-Gamarra, Jose Miguel; Salazar-Tortosa, Diego; Labayen, Idoia; Rupérez, Azahara I.; Leclercq, Catherine; Marcos, Ascensión ; Gómez Martínez, Sonia ; Moreno, Luis A.; Meirhaeghe, A.; Castillo, Manuel J.; Ruiz, Jonatan R.
Issue Date2020
PublisherSpringer Nature
CitationPediatric Research 88: 265–270 (2020)
Abstract[Background]: Cardiovascular diseases (CVDs) are responsible for 31% of all deaths worldwide. Genetic predisposition to CVDs in adolescents remains largely unknown. The aim of this study was to examine the association of UCP1, UCP2 and UCP3 gene polymorphisms with CVD risk factors in European adolescents.
[Method]: A cross-sectional study that involves 1.057 European adolescents (12–18 years old) from the HELENA study. A total of 18 polymorphisms of UCP1, UCP2 and UCP3 genes were genotyped. We measured serum total cholesterol, high-density lipoprotein,low-density lipoprotein, ApoA1, ApoB, leptin, triglycerides, glucose, insulin and blood pressure, and calculated HOMA (homeostatic model assessment), Quantitative Insulin Sensitivity Check Index (QUICKI) and a CVD risk score.
[Results]: The G allele of UCP2 rs2735572 and T allele of UCP2 rs17132534 were associated with higher diastolic blood pressure (P = 0.001; false discovery rate [FDR] = 0.009 and P = 8e–04; FDR = 0.009, respectively). We observed that the AATAG haplotype of UCP1 was associated with higher serum ApoB/ApoA1 (P = 0.008; FDR = 0.031) and ApoB levels (P = 0.008; FDR = 0.031). Moreover, the ACC haplotype of UCP3 was associated with a higher CVD risk score (P = 0.0036; FDR = 0.01).
[Conclusions]: Two UCP2 polymorphisms and haplotypes of UCP1 and UCP3 were associated with CVD risk factors. These findings suggest that UCPs may have a role in the development of CVD already in adolescents.
Publisher version (URL)https://doi.org/10.1038/s41390-019-0735-7
URIhttp://hdl.handle.net/10261/219333
DOIhttp://dx.doi.org/10.1038/s41390-019-0735-7
ISSN0031-3998
E-ISSN1530-0447
Appears in Collections:(ICTAN) Artículos
Files in This Item:
File Description SizeFormat 
assoHelen.pdf586,82 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.