English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/219331
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:


Association between lipoprotein lipase gene polymorphisms and cardiovascular disease risk factors in European adolescents: The healthy lifestyle in Europe by nutrition in adolescence study

AuthorsSalazar-Tortosa, Diego; Pascual-Gamarra, Jose Miguel; Labayen, Idoia; Rupérez, Azahara I.; Censi, Laura; Béghin, Laurent; Michels, Nathalie; González Gross, Marcela; Manios, Yannis; Lambrinou, Christina-Paulina; Marcos, Ascensión ; Moreno, Luis A.; Meirhaeghe, A.; Castillo, Manuel J.; Ruiz, Jonatan R.
Issue Date2020
CitationPediatric Diabetes 21(5): 747-757 (2020)
Abstract[Objectives]: To examine the association of lipoprotein lipase (LPL) polymorphisms with cardiovascular disease (CVD) risk factors in European adolescents, along with the influence of physical activity on these associations.
[Methods]: A total of 13 LPL polymorphisms were genotyped in 1.057 European adolescents (12‐18 years old) from the Healthy Lifestyle in Europe by Nutrition in Adolescence Cross‐Sectional Study. Serum lipids, glucose, insulin, and leptin (LEP) levels were measured and a CVD risk score was computed. We also measured body weight and height, waist and hip circumferences, and triceps and subscapular skinfold thickness. Physical activity was objectively measured by accelerometry for 7 days.
[Results]: The rs1534649, rs258, rs320, and rs328 polymorphisms were associated with several CVD risk factors (ie, body mass index, triglycerides [TG], LEP, and cholesterol/high‐density lipoprotein [HDL], low‐density lipoprotein [LDL]/HDL, TG/HDL ratios). TG and TG/HDL were associated with haplotype blocks 3 (rs282, rs285 polymorphisms) and 4 (rs3126, rs320, rs328, rs10099160 polymorphisms), being the latter also associated with the CVD risk score. Physical activity modulated the association of adiposity with rs1534649 and rs258 polymorphisms.
[Conclusions]: Polymorphisms rs1534649, rs258, rs320 and rs328, and two haplotypes of LPL were significantly associated with CVD risk factors in European adolescents. Higher levels of moderate to vigorous physical activity may attenuate the effects of rs1534649 and rs258 polymorphisms on adiposity.
Publisher version (URL)https://doi.org/10.1111/pedi.13035
Appears in Collections:(ICTAN) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf59,24 kBAdobe PDFThumbnail
Show full item record
Review this work

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.