English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/219148
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:


The influence of cation incorporation and leaching in the properties of Mn-doped nanoparticles for biomedical applications

AuthorsGarcía-Soriano, David; Amaro, Rebeca; Lafuente-Gómez, Nuria; Milán-Rois, Paula; Somoza, Álvaro; Navío, Cristina; Herranz, Fernando ; Gutiérrez, Lucía ; Salas, Gorka
KeywordsMagnetic nanoparticles
Colloidal ferrites
Cation doping
Issue Date2020
CitationJournal of Colloid and Interface Science 578: 510-521 (2020)
Abstract[Hypothesis]: Superparamagnetic MnxFe3-xO4 nanoparticles are promising materials for applications in biomedicine and other fields. Small variations in the Mn/Fe ratio have a strong impact on the properties of the nanoparticles. Those variations may be caused by the synthesis itself and by common post-synthesis manipulations like surface modification.
[Experiments]: Mn-ferrite nanoparticles have been prepared changing systematically the Mn/Fe ratio of the metal precursors and repeating each reaction three times. Nanoparticles were subjected to surface modification with two different and typical molecules to stabilize them in aqueous media. The discrepancy in the Mn/Fe ratios of the precursors with the ones measured after the synthesis and the surface modification have been studied, as well as its impact on the saturation magnetization, blocking temperature, contrast enhancement for magnetic resonance imaging, magnetic heating, and on the cytotoxicity.
[Findings]: Mn is incorporated in the nanoparticles in a relatively lower amount than Fe and, as this report shows for the first time, both Mn and Fe ions leach out from the nanoparticles during the surface modification step. The blocking temperature decreases exponentially as the Mn/Fe ratio increases. The transverse and longitudinal relaxation times and the magnetic heating ability change appreciably even with small variations in the composition.
Publisher version (URL)https://doi.org/10.1016/j.jcis.2020.06.011
Appears in Collections:(IQM) Artículos
(CNB) Artículos
(ICMA) Artículos
Files in This Item:
File Description SizeFormat 
manuscript ferrites_JCIS_2nd revised.pdf Embargoed until June 6, 20221,84 MBAdobe PDFThumbnail
View/Open    Request a copy
Show full item record
Review this work

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.