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dc.contributor.authorSong, Cunfenges_ES
dc.contributor.authorLi, Yuminges_ES
dc.contributor.authorLi, Tianlianges_ES
dc.contributor.authorHuang, Zhichenges_ES
dc.contributor.authorFuente, Jesús M. de laes_ES
dc.contributor.authorNi, Jianes_ES
dc.contributor.authorCui, Daxianges_ES
dc.date.accessioned2020-09-02T11:11:48Z-
dc.date.available2020-09-02T11:11:48Z-
dc.date.issued2020-
dc.identifier.citationAdvanced Functional Materials 30(11): 1906309 (2020)es_ES
dc.identifier.issn1616-301X-
dc.identifier.urihttp://hdl.handle.net/10261/219010-
dc.description.abstractNanocarriers for chemo‐photothermal therapy suffer from insufficient retention at the tumor site and poor penetration into tumor parenchyma. A smart drug‐dye‐based micelle is designed by making the best of the structural features of small‐molecule drugs. P‐DOX is synthesized by conjugating doxorubicin (DOX) with poly(4‐formylphenyl methacrylate‐co‐2‐(diethylamino) ethyl methacrylate)‐b‐polyoligoethyleneglycol methacrylate (P(FPMA‐co‐DEA)‐b‐POEGMA) via imine linkage. Through the π–π stacking interaction, IR780, a near‐infrared fluorescence dye as well as a photothermal agent, is integrated into the micelles (IR780‐PDMs) with the P‐DOX. The IR780‐PDMs show remarkably long blood circulation (t1/2β = 22.6 h). As a result, a progressive tumor accumulation and retention are presented, which is significant to the sequential drug release. Moreover, when entering into a moderate acidic tumor microenvironment, IR780‐PDMs can dissociate into small‐size conjugates and IR780, which obviously increases the penetration depth of drugs, and then improves the lethality to deep‐seated tumor cells. Owing to the high delivery efficiency and superior chemo‐photothermal therapeutic efficacy of IR780‐PDMs, 97.6% tumor growth in the A549 tumor‐bearing mice is suppressed with a low dose of intravenous injection (DOX, 1.5 mg kg−1; IR780, 0.8 mg kg−1). This work presents a brand‐new strategy for long‐acting intensive cancer therapy.es_ES
dc.description.sponsorshipThe authors acknowledge the financial support of the National Key Basic Research Program (no. 2017FYA0205301 and no. 2010CB933901), the Natural Science Foundation of China (no. 81921002 and no. 81327002), and the China Postdoctoral Science Foundation (no. 2018M642026).es_ES
dc.language.isoenges_ES
dc.publisherWiley-VCHes_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rightsopenAccesses_ES
dc.titleLong‐circulating drug‐dye‐based micelles with ultrahigh pH‐sensitivity for deep tumor penetration and superior chemo‐photothermal therapyes_ES
dc.typeartículoes_ES
dc.identifier.doi10.1002/adfm.201906309-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttps://doi.org/10.1002/adfm.201906309es_ES
dc.identifier.e-issn1616-3028-
dc.rights.licensehttp://creativecommons.org/licenses/by-nc/4.0/es_ES
dc.contributor.funderNational Natural Science Foundation of Chinaes_ES
dc.contributor.funderNational Key Research and Development Program (China)es_ES
dc.contributor.funderChina Postdoctoral Science Foundationes_ES
dc.relation.csices_ES
oprm.item.hasRevisionno ko 0 false*
dc.identifier.funderhttp://dx.doi.org/10.13039/501100001809es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100002858es_ES
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.openairetypeartículo-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.grantfulltextopen-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
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