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Peptides mimicking the β7/β8 loop of HIV'1 reverse transcriptase p51 as “hotspot-targeted” dimerization inhibitors

AuthorsSánchez-Murcia, P. A.; Castro, Sonia de ; García-Aparicio, Carlos ; Jiménez, M. Angeles ; Corona, A.; Tramontano, Enzo; Sluis-Cremer, N.; Menéndez-Arias, Luis ; Velázquez, Sonsoles ; Gago, Federico ; Camarasa Rius, María José
KeywordsConstrained peptides
Dimerization hotspot
Dimerization inhibitors
HIV reverse transcriptase.
Issue Date2020
PublisherAmerican Chemical Society
CitationACS Medicinal Chemistry Letters 11: 811-817 (2020)
AbstractA conformationally constrained short peptide designed to target a protein−protein interaction hotspot in HIV-1 reverse transcriptase (RT) disrupts p66-p51 interactions and paves the way to the development of novel RT dimerization inhibitors.
Publisher version (URL)http://dx.doi.org/10.1021/acsmedchemlett.9b00623
Identifiersdoi: 10.1021/acsmedchemlett.9b00623
issn: 1948-5875
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