English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/218938
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Polymorphic Inversions Underlie the Shared Genetic Susceptibility of Obesity-Related Diseases

AuthorsGonzález, Juan R.; Ruiz-Arenas, Carlos; Cáceres, Alejandro; Morán, Ignasi; López Sánchez, Marcos; Alonso, Lorena; Tolosana, Ignacio; Guindo-Martínez, M.; Mercader, Josep M.; Esko, Tonu; Torrents, David; González Pérez, Josefa ; Pérez-Jurado, Luis A.
Issue Date4-Jun-2020
PublisherElsevier
CitationAmerican Journal of Human Genetics 106(6): 846-858 (2020)
AbstractThe burden of several common diseases including obesity, diabetes, hypertension, asthma, and depression is increasing in most world populations. However, the mechanisms underlying the numerous epidemiological and genetic correlations among these disorders remain largely unknown. We investigated whether common polymorphic inversions underlie the shared genetic influence of these disorders. We performed an inversion association analysis including 21 inversions and 25 obesity-related traits on a total of 408,898 Europeans and validated the results in 67,299 independent individuals. Seven inversions were associated with multiple diseases while inversions at 8p23.1, 16p11.2, and 11q13.2 were strongly associated with the co-occurrence of obesity with other common diseases. Transcriptome analysis across numerous tissues revealed strong candidate genes for obesity-related traits. Analyses in human pancreatic islets indicated the potential mechanism of inversions in the susceptibility of diabetes by disrupting the cis-regulatory effect of SNPs from their target genes. Our data underscore the role of inversions as major genetic contributors to the joint susceptibility to common complex diseases.
Publisher version (URL)https://doi.org/10.1016/j.ajhg.2020.04.017
URIhttp://hdl.handle.net/10261/218938
DOI10.1016/j.ajhg.2020.04.017
ISSN0002-9297
E-ISSN1537-6605
Appears in Collections:(IBE) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf59,24 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.