English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/218878
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:


BSA- and elastin-coated GO, but not collagen-coated GO, enhance the biological performance of alginate hydrogels

AuthorsRaslan, Ahmed; Saenz del Burgo, Laura; Espona-Noguera, Albert; Ochoa de Retana, Ana María; Sanjuán, M. L.; Cañibano-Hernández, Alberto; Gálvez-Martín, Patricia; Ciriza, Jesús; Pedraz, Jose Luis
Issue Date2020
PublisherMultidisciplinary Digital Publishing Institute
CitationPharmaceutics 12(6): 543 (2020)
AbstractThe use of embedded cells within alginate matrices is a developing technique with great clinical applications in cell-based therapies. However, one feature that needs additional investigation is the improvement of alginate-cells viability, which could be achieved by integrating other materials with alginate to improve its surface properties. In recent years, the field of nanotechnology has shown the many properties of a huge number of materials. Graphene oxide (GO), for instance, seems to be a good choice for improving alginate cell viability and functionality. We previously observed that GO, coated with fetal bovine serum (FBS) within alginate hydrogels, improves the viability of embedded myoblasts. In the current research, we aim to study several proteins, specifically bovine serum albumin (BSA), type I collagen and elastin, to discern their impact on the previously observed improvement on embedded myoblasts within alginate hydrogels containing GO coated with FBS. Thus, we describe the mechanisms of the formation of BSA, collagen and elastin protein layers on the GO surface, showing a high adsorption by BSA and elastin, and a decreasing GO impedance and capacitance. Moreover, we described a better cell viability and protein release from embedded cells within hydrogels containing protein-coated GO. We conclude that these hybrid hydrogels could provide a step forward in regenerative medicine.
DescriptionThis article belongs to the Section Drug Delivery and Controlled Release.
Publisher version (URL)https://doi.org/10.3390/pharmaceutics12060543
Appears in Collections:(ICMA) Artículos
Files in This Item:
File Description SizeFormat 
BSA - GO.pdf4,28 MBAdobe PDFThumbnail
Show full item record
Review this work

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.