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BODIPYs revealing lipid droplets as valuable targets for photodynamic theragnosis

AuthorsTabero, Andrea; García-Garrido, F.; Prieto-Castañeda, A.; Palao, E.; Agarrabeitia, A.R.; Garcia-Moreno, I. ; Villanueva, A.; De La Moya, S.; Ortiz, M.J.
Issue Date11-Dec-2019
PublisherRoyal Society of Chemistry (UK)
CitationChemical Communications 56: 940-943 (2020)
AbstractEndowing BODIPY PDT agents with the ability to probe lipid droplets is demonstrated to boost their phototoxicity, allowing the efficient use of highly fluorescent dyes (poor ROS sensitizers) as phototoxic agents. Conversely, this fact opens the way to the development of highly bright ROS photosensitizers for performing photodynamic theragnosis (fluorescence bioimaging and photodynamic therapy) from a single simple agent. On the other hand, the noticeable capability of some of the reported dyes to probe lipid droplets in different cell lines under different conditions reveals their use as privileged probes for advancing the study of interesting lipid droplets by fluorescence microscopy.
Description4 pags., 3 figs., 1 tab.
Publisher version (URL)http://dx.doi.org/10.1039/c9cc09397d
Identifiersdoi: 10.1039/c9cc09397d
issn: 1364-548X
Appears in Collections:(IQFR) Artículos
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