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Title

Luminescent silicon-based nanocarrier for drug delivery in colorectal cancer cells

AuthorsMarcelo, Gonçalo A.; Montpeyó, D.; Novio, Fernando ; Ruiz Molina, Daniel ; Lorenzo, Julia ; Oliveira, Elisabete
Issue Date2020
PublisherElsevier
CitationDyes and Pigments 181: 108393 (2020)
AbstractNanocarriers sensitive to exogenous or endogenous stimuli emerged as an attractive alternative to target drug delivery, with inorganic silica mesoporous nanoparticles (MNs) playing a core role in the development of a new generation of non-toxic and tuneable nanocarriers. A sensitive nanovector (NANO1) comprising luminescent silicon quantum dots (SiQDs) and functionalized with MNs was synthesised and loaded with doxorubicin (DOX). NANO1 nanoparticles have a size of 74 ± 10 nm and DOX loading percentages of ca. 43%. As a control sample, a similar nanocarrier (NANO2), without SiQDs, was also synthesised and loaded with DOX. Release profile studies, in PBS, revealed the strong NANO1@DOX pH-dependant behaviour, with a pH 5.0 favouring the release of DOX to percentages of ca. 70%. Cytotoxicity assessments of both free and DOX-loaded nanocarriers were evaluated in human cell lines of colon, revealing both free drug and drug-loaded nanoparticles to be concentration-dependent.
Publisher version (URL)https://doi.org/10.1016/j.dyepig.2020.108393
URIhttp://hdl.handle.net/10261/218772
DOIhttp://dx.doi.org/10.1016/j.dyepig.2020.108393
ISSN0143-7208
Appears in Collections:(CIN2) Artículos
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