English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/218746
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:

Title

Cerium oxide nanoparticles: Advances in biodistribution, toxicity, and preclinical exploration

AuthorsCasals, Eudald ; Zeng, Mulling; Parra-Robert, Marina; Fernández-Varo, Guillermo; Morales-Ruiz, Manuel; Jiménez, Wladimiro; Puntes, Víctor F. ; Casals, Gregori
Issue Date2020
PublisherWiley-VCH
CitationSmall 16(20): 1907322 (2020)
AbstractAntioxidant nanoparticles have recently gained tremendous attention for their enormous potential in biomedicine. However, discrepant reports of either medical benefits or toxicity, and lack of reproducibility of many studies, generate uncertainties delaying their effective implementation. Herein, the case of cerium oxide is considered, a well‐known catalyst in the petrochemistry industry and one of the first antioxidant nanoparticles proposed for medicine. Like other nanoparticles, it is now described as a promising therapeutic alternative, now as threatening to health. Sources of these discrepancies and how this analysis helps to overcome contradictions found for other nanoparticles are summarized and discussed. For the context of this analysis, what has been reported in the liver is reviewed, where many diseases are related to oxidative stress. Since well‐dispersed nanoparticles passively accumulate in liver, it represents a major testing field for the study of new nanomedicines and their clinical translation. Even more, many contradictory works have reported in liver either cerium‐oxide‐associated toxicity or protection against oxidative stress and inflammation. Based on this, finally, the intention is to propose solutions to design improved nanoparticles that will work more precisely in medicine and safely in society.
Publisher version (URL)https://doi.org/10.1002/smll.201907322
URIhttp://hdl.handle.net/10261/218746
DOIhttp://dx.doi.org/10.1002/smll.201907322
ISSN1613-6810
E-ISSN1613-6829
Appears in Collections:(CIN2) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf59,24 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.