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Title

Analytical quality assurance in veterinary drug residue analysis methods: Matrix effects determination and monitoring for sulfonamides analysis

AuthorsHoff, R.B.; Rübensam, G.; Jank, L.; Barreto, F.; Ruaro Peralba, M.D.C.; Pizzolato, T.M.; Díaz-Cruz, M. Silvia ; Barceló, Damià
Issue Date2015
PublisherElsevier BV
CitationTalanta 132: 443- 450 (2015)
Abstract© 2014 Elsevier Ltd. All rights reserved. In residue analysis of veterinary drugs in foodstuff, matrix effects are one of the most critical points. This work present a discuss considering approaches used to estimate, minimize and monitoring matrix effects in bioanalytical methods. Qualitative and quantitative methods for estimation of matrix effects such as post-column infusion, slopes ratios analysis, calibration curves (mathematical and statistical analysis) and control chart monitoring are discussed using real data. Matrix effects varying in a wide range depending of the analyte and the sample preparation method: pressurized liquid extraction for liver samples show matrix effects from 15.5 to 59.2% while a ultrasound-assisted extraction provide values from 21.7 to 64.3%. The matrix influence was also evaluated: for sulfamethazine analysis, losses of signal were varying from -37 to -96% for fish and eggs, respectively. Advantages and drawbacks are also discussed considering a workflow for matrix effects assessment proposed and applied to real data from sulfonamides residues analysis.
Publisher version (URL)http://dx.doi.org/10.1016/j.talanta.2014.08.046
URIhttp://hdl.handle.net/10261/218705
Identifiersdoi: 10.1016/j.talanta.2014.08.046
issn: 0039-9140
Appears in Collections:(IDAEA) Artículos
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