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Membrane curvature induces cardiolipin sorting

AuthorsBeltrán-Heredia, E.; Tsai, F. C.; Salinas-Almaguer, S.; Cao, F. J.; Bassereau, P.; Monroy, F.
Issue Date20-Jun-2019
PublisherNature Publishing Group
CitationCommunications Biology ) 2:225 (2019)
AbstractCardiolipin is a cone-shaped lipid predominantly localized in curved membrane sites of bacteria and in the mitochondrial cristae. This specific localization has been argued to be geometry-driven, since the CL’s conical shape relaxes curvature frustration. Although previous evidence suggests a coupling between CL concentration and membrane shape in vivo, no precise experimental data are available for curvature-based CL sorting in vitro. Here, we test this hypothesis in experiments that isolate the effects of membrane curvature in lipid-bilayer nanotubes. CL sorting is observed with increasing tube curvature, reaching a maximum at optimal CL concentrations, a fact compatible with self-associative clustering. Observations are compatible with a model of membrane elasticity including van der Waals entropy, from which a negative intrinsic curvature of −1.1 nm is predicted for CL. The results contribute to understanding the physicochemical interplay between membrane curvature and composition, providing key insights into mitochondrial and bacterial membrane organization and dynamics.
Description7 pags., 3 figs.
Publisher version (URL)http://dx.doi.org/10.1038/s42003-019-0471-x
Identifiersdoi: 10.1038/s42003-019-0471-x
issn: 2399-3642
Appears in Collections:(CFMAC-IEM) Artículos
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