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Título: | Membrane curvature induces cardiolipin sorting |
Autor: | Beltrán-Heredia, E.; Tsai, F. C.; Salinas-Almaguer, S.; Cao, Francisco J.; Bassereau, P.; Monroy, F. | Fecha de publicación: | 20-jun-2019 | Editor: | Nature Publishing Group | Citación: | Communications Biology ) 2:225 (2019) | Resumen: | Cardiolipin is a cone-shaped lipid predominantly localized in curved membrane sites of bacteria and in the mitochondrial cristae. This specific localization has been argued to be geometry-driven, since the CL’s conical shape relaxes curvature frustration. Although previous evidence suggests a coupling between CL concentration and membrane shape in vivo, no precise experimental data are available for curvature-based CL sorting in vitro. Here, we test this hypothesis in experiments that isolate the effects of membrane curvature in lipid-bilayer nanotubes. CL sorting is observed with increasing tube curvature, reaching a maximum at optimal CL concentrations, a fact compatible with self-associative clustering. Observations are compatible with a model of membrane elasticity including van der Waals entropy, from which a negative intrinsic curvature of −1.1 nm is predicted for CL. The results contribute to understanding the physicochemical interplay between membrane curvature and composition, providing key insights into mitochondrial and bacterial membrane organization and dynamics. | Descripción: | 7 pags., 3 figs. | Versión del editor: | http://dx.doi.org/10.1038/s42003-019-0471-x | URI: | http://hdl.handle.net/10261/218648 | DOI: | 10.1038/s42003-019-0471-x | Identificadores: | doi: 10.1038/s42003-019-0471-x issn: 2399-3642 |
Aparece en las colecciones: | (CFMAC-IEM) Artículos |
Ficheros en este ítem:
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Membrane curvature.pdf | 1,53 MB | Adobe PDF | Visualizar/Abrir | |
Supplementary Information (2).pdf | 1,25 MB | Adobe PDF | Visualizar/Abrir |
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