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dc.contributor.authorAmigo, Lourdes-
dc.contributor.authorMartínez-Maqueda, D.-
dc.contributor.authorHernández-Ledesma, Blanca-
dc.date.accessioned2020-08-21T13:54:02Z-
dc.date.available2020-08-21T13:54:02Z-
dc.date.issued2020-
dc.identifier.citationFoods 9(8): 991 (2020)-
dc.identifier.urihttp://hdl.handle.net/10261/218426-
dc.descriptionThis article belongs to the Special Issue New Advances in the Research of Antioxidant Food Peptides.-
dc.description.abstractCurrently, the associations between oxidative stress, inflammation, hypertension, and metabolic disturbances and non-communicable diseases are very well known. Since these risk factors show a preventable character, the searching of food peptides acting against them has become a promising strategy for the design and development of new multifunctional foods or nutraceuticals. In the present study, an integrated approach combining an in silico study and in vitro assays was used to confirm the multifunctionality of milk and meat protein-derived peptides that were similar to or shared amino acids with previously described opioid peptides. By the in silico analysis, 15 of the 27 assayed peptides were found to exert two or more activities, with Angiotensin-converting enzyme (ACE) inhibitory, antioxidant, and opioid being the most commonly found. The in vitro study confirmed ACE-inhibitory and antioxidant activities in 15 and 26 of the 27 synthetic peptides, respectively. Four fragments, RYLGYLE, YLGYLE, YFYPEL, and YPWT, also demonstrated the ability to protect Caco-2 and macrophages RAW264.7 cells from the oxidative damage caused by chemicals. The multifunctionality of these peptides makes them promising agents against oxidative stress-associated diseases.-
dc.description.sponsorshipThis research was funded by project AGL2015- 66886-R from the Spanish Ministry of Science and Innovation (MICIU).-
dc.language.isoeng-
dc.publisherMultidisciplinary Digital Publishing Institute-
dc.relationMINECO/ICTI2013-2016/AGL2015-66886-R-
dc.relation.isversionofPublisher’s version-
dc.rightsopenAccess-
dc.subjectBioactive peptides-
dc.subjectAnimal protein-
dc.subjectMultifunctionality-
dc.subjectAntioxidant activity-
dc.subjectIn silico-
dc.subjectCell models-
dc.titleIn silico and in vitro analysis of multifunctionality of animal food-derived peptides-
dc.typeartículo-
dc.identifier.doihttp://dx.doi.org/10.3390/foods9080991-
dc.description.peerreviewedPeer reviewed-
dc.relation.publisherversionhttps://doi.org/10.3390/foods9080991-
dc.identifier.e-issn2304-8158-
dc.date.updated2020-08-21T13:54:03Z-
dc.rights.licensehttp://creativecommons.org/licenses/by/4.0/-
dc.contributor.funderMinisterio de Economía y Competitividad (España)-
dc.relation.csic-
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003329es_ES
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