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Genetic regulatory mechanisms of cerebral cortex expansion in amniote evolution

AuthorsEspinós, Alexandre; Fernández, Santiago; Cárdenas, Adrián; Borrell, V.
Issue Date2019
CitationEuropean Developmental Biology Congress (2019)
AbstractCerebral cortex size and complexity varies greatly across amniote phylogeny. In species with a small and simple cortex, like reptiles and small birds, the vast majority of neurons are born directly from apical Radial Glia Cells (aRGCs), whereas in mammals most neocortical neurons are born indirectly via the production of Intermediate Progenitors Cells (IPCs), which greatly amplify the neurogenic output of aRGCs. Thus, the balance between direct and indirect neurogenesis is crucial for cortical growth. A previous study recently carried out in our lab demonstrated that high levels of Robo1 and Robo2 expression in aRGCs lead to low levels of Dll1 and promote direct neurogenesis, while low Robo1/2 and high Dll1 lead to production of IPCs and indirect neurogenesis. Most importantly, this mechanism is conserved in amniote phylogeny, from reptiles to humans, indicating that attenuation of Robo signaling during evolution led to the emergence of IPCs and expansion of the cerebral cortex. We hypothesize that these differences are due to changes in the mechanisms that regulate Robo transcription. Here we use BrdU labeling in vivo, and two-photon videomicroscopy of brain slices, to precisely define the frequency of occurrence of direct and indirect neurogenesis along embryonic development in both mouse and chick. This will lead us to identify the most relevant stages to search for variations in the regulation of Robo transcription across developmental time within and between species.
DescriptionResumen del póster presentado al European Developmental Biology Congress (EDBC), celebrado en Alicante del 23 al 26 de octubre de 2019.
Appears in Collections:(IN) Comunicaciones congresos
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