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dc.contributor.authorMurcia-Belmonte, Verónicaes_ES
dc.contributor.authorErskine, Lyndaes_ES
dc.date.accessioned2020-08-17T08:02:37Z-
dc.date.available2020-08-17T08:02:37Z-
dc.date.issued2019-
dc.identifier.citationInternational Journal of Molecular Sciences 20(13): 3282 (2019)es_ES
dc.identifier.issn1661-6596-
dc.identifier.urihttp://hdl.handle.net/10261/218051-
dc.descriptionThis article belongs to the Special Issue Retinal Ganglion Cells.es_ES
dc.description.abstractRetinal ganglion cells (RGCs) extend axons out of the retina to transmit visual information to the brain. These connections are established during development through the navigation of RGC axons along a relatively long, stereotypical pathway. RGC axons exit the eye at the optic disc and extend along the optic nerves to the ventral midline of the brain, where the two nerves meet to form the optic chiasm. In animals with binocular vision, the axons face a choice at the optic chiasm—to cross the midline and project to targets on the contralateral side of the brain, or avoid crossing the midline and project to ipsilateral brain targets. Ipsilaterally and contralaterally projecting RGCs originate in disparate regions of the retina that relate to the extent of binocular overlap in the visual field. In humans virtually all RGC axons originating in temporal retina project ipsilaterally, whereas in mice, ipsilaterally projecting RGCs are confined to the peripheral ventrotemporal retina. This review will discuss recent advances in our understanding of the mechanisms regulating specification of ipsilateral versus contralateral RGCs, and the differential guidance of their axons at the optic chiasm. Recent insights into the establishment of congruent topographic maps in both brain hemispheres also will be discussed.es_ES
dc.description.sponsorshipV.M.-B. holds a postdoctoral contract from the Generalitat Valenciana (APOSTD/2016/017).es_ES
dc.language.isoenges_ES
dc.publisherMultidisciplinary Digital Publishing Institutees_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rightsopenAccesses_ES
dc.subjectAxon guidancees_ES
dc.subjectRetinaes_ES
dc.subjectProgenitor celles_ES
dc.subjectNeurogenesises_ES
dc.titleWiring the binocular visual pathwayses_ES
dc.typeartículoes_ES
dc.identifier.doihttp://dx.doi.org/10.3390/ijms20133282-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttps://doi.org/10.3390/ijms20133282es_ES
dc.identifier.e-issn1422-0067-
dc.rights.licensehttps://creativecommons.org/licenses/by/4.0/es_ES
dc.contributor.funderGeneralitat Valencianaes_ES
dc.relation.csices_ES
oprm.item.hasRevisionno ko 0 false*
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003359es_ES
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