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dc.contributor.authorQuiñones Colomer, Darío Rubénes_ES
dc.contributor.authorFernández-Mollá, Luis Migueles_ES
dc.contributor.authorPacheco-Torres, Jesúses_ES
dc.contributor.authorCaramés, José M.es_ES
dc.contributor.authorCanals Gamoneda, Santiagoes_ES
dc.contributor.authorMoratal, Davides_ES
dc.date.accessioned2020-08-14T11:34:58Z-
dc.date.available2020-08-14T11:34:58Z-
dc.date.issued2019-
dc.identifier.citationMagnetic Resonance Imaging 58: 67-75 (2019)es_ES
dc.identifier.issn0730-725X-
dc.identifier.urihttp://hdl.handle.net/10261/218004-
dc.description.abstract[Introduction]: Functional magnetic resonance imaging (fMRI) is one of the most highly regarded techniques in the neuroimaging field. This technique is based on vascular responses to neuronal activation and is extensively used in clinical and animal research studies. In preclinical settings, fMRI is usually applied to anesthetized animals. However, anesthetics cause alterations, e.g. hypothermia, in the physiology of the animals and this has the potential to disrupt fMRI signals. The current temperature control method involves a technician, as well as monitoring the acquisition MRI sequences, also controlling the temperature of the animal; this is inefficient.es_ES
dc.description.abstract[Methods]: In order to avoid hypothermia in anesthetized rodents an Open-Source automatic temperature control device is presented. It takes signals from an intrarectal temperature sensor, as well as signals from a thermal bath, which warms up the body of the animal under study, in order to determine the mathematical model of the thermal response of the animal.es_ES
dc.description.abstract[Results]: A Proportional-Integral-Derivative (PID) algorithm, which was discretized in an Arduino microcontroller, was developed to automatically keep stable the body temperature of the animal under study. The PID algorithm has been shown to be accurate in preserving the body temperature of the animal.es_ES
dc.description.abstract[Conclusion]: This work presents the TherMouseDuino. It is an Open-Source automatic temperature control system and reduces temperature fluctuations, thus providing robust conditions in which to perform fMRI experiments. Furthermore, our device frees up the technician to focus solely on monitoring the MRI sequences.es_ES
dc.description.sponsorshipThis work was supported in part by the Spanish Ministerio de Economía y Competitividad (MINECO) and FEDER funds under grants BFU2015-64380-C2-2-R (D.M.) and BFU2015-64380-C2-1-R and EU Horizon 2020 Program 668863-SyBil-AA grant (S.C.). S.C. acknowledges financial support from the Spanish State Research Agency, through the “Severo Ochoa” Programme for Centres of Excellence in R&D (ref. SEV-2013-0317). D.R.Q. was supported by grant “Ayudas para la formación de personal investigador (FPI)” from the Vicerrectorado de Investigación, Innovación y Transferencia of the Universitat Politècnica de València.es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relationMINECO/ICTI2013-2016/BFU2015-64380-C2-2-Res_ES
dc.relationMINECO/ICTI2013-2016/BFU2015-64380-C2-1-Res_ES
dc.relationinfo:eu-repo/grantAgreement/EC/H2020/668863es_ES
dc.relationMINECO/ICTI2013-2016/SEV-2013-0317es_ES
dc.rightsclosedAccesses_ES
dc.subjectAnesthetices_ES
dc.subjectArduinoes_ES
dc.subjectBOLDes_ES
dc.subjectPIDes_ES
dc.titleTherMouseDuino: An affordable Open-Source temperature control system for functional magnetic resonance imaging experimentation with micees_ES
dc.typeartículoes_ES
dc.identifier.doihttp://dx.doi.org/10.1016/j.mri.2019.01.009-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttps://doi.org/10.1016/j.mri.2019.01.009es_ES
dc.contributor.funderMinisterio de Economía y Competitividad (España)es_ES
dc.contributor.funderEuropean Commissiones_ES
dc.contributor.funderAgencia Estatal de Investigación (España)es_ES
dc.contributor.funderUniversidad Politécnica de Valenciaes_ES
dc.relation.csices_ES
oprm.item.hasRevisionno ko 0 false*
dc.identifier.funderhttp://dx.doi.org/10.13039/501100011033es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003329es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000780es_ES
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