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dc.contributor.authorFernández-Nogales, Martaes_ES
dc.contributor.authorMurcia-Belmonte, Verónicaes_ES
dc.contributor.authorChen, Holly Yues_ES
dc.contributor.authorHerrera, Eloisaes_ES
dc.date.accessioned2020-08-14T11:23:38Z-
dc.date.available2020-08-14T11:23:38Z-
dc.date.issued2019-
dc.identifier.citationProgress in Retinal and Eye Research 68: 110-123 (2019)es_ES
dc.identifier.issn1350-9462-
dc.identifier.urihttp://hdl.handle.net/10261/218003-
dc.description.abstractNumerous degenerative diseases affecting visual function, including glaucoma and retinitis pigmentosa, are produced by the loss of different types of retinal cells. Cell replacement therapy has emerged as a promising strategy for treating these and other retinal diseases. The retinal margin or ciliary body (CB) of mammals has been proposed as a potential source of cells to be used in degenerative conditions affecting the retina because it has been reported it might hold neurogenic potential beyond embryonic development. However, many aspects of the origin and biology of the CB are unknown and more recent experiments have challenged the capacity of CB cells to generate different types of retinal neurons. Here we review the most recent findings about the development of the marginal zone of the retina in different vertebrates and some of the mechanisms underlying the proliferative and neurogenic capacity of this fascinating region of the vertebrates eye. In addition, we performed experiments to isolate CB cells from the mouse retina, generated neurospheres and observed that they can be expanded with a proliferative ratio similar to neural stem cells. When induced to differentiate, cells derived from the CB neurospheres start to express early neural markers but, unlike embryonic stem cells, they are not able to fully differentiate in vitro or generate retinal organoids. Together with previous reports on the neurogenic capacity of CB cells, also reviewed here, our results contribute to the current knowledge about the potentiality of this peripheral region of the eye as a therapeutic source of functional retinal neurons in degenerative diseases.es_ES
dc.description.sponsorshipSupported by a Prometeo Grant (REF, 2012-005; Generalitat Valenciana), a national grant (BFU2016-77605-P; PCIN-2015-192-C02-02), Fundación Marató (20142130), European Grant (ERC2011-StG201001109) to support work in the laboratory of EH. The Instituto de Neurociencias is a Severo Ochoa Excellence Center (SEV-2013-0317). MFN holds a “Juan de la Cierva” contract from the Spanish Government and VMB holds a postdoctoral contract from the Regional Government. The development of organoid protocol was supported by intramural research program of the National Eye Institute (EY000450, EY000474).es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relationMINECO/ICTI2013-2016/BFU2016-77605-Pes_ES
dc.relationMINECO/ICTI2013-2016/PCIN-2015-192-C02-02es_ES
dc.relationMINECO/ICTI2013-2016/SEV-2013-0317es_ES
dc.rightsclosedAccesses_ES
dc.subjectCiliary marginal zonees_ES
dc.subjectCiliary bodyes_ES
dc.subjectRetinaes_ES
dc.subjectEye neurogenesises_ES
dc.titleThe peripheral eye: A neurogenic area with potential to treat retinal pathologies?es_ES
dc.typeartículoes_ES
dc.identifier.doihttp://dx.doi.org/10.1016/j.preteyeres.2018.09.001-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttps://doi.org/10.1016/j.preteyeres.2018.09.001es_ES
dc.contributor.funderMinisterio de Economía y Competitividad (España)es_ES
dc.contributor.funderGeneralitat Valencianaes_ES
dc.contributor.funderEuropean Commissiones_ES
dc.contributor.funderEuropean Research Counciles_ES
dc.contributor.funderFundació La Marató de TV3es_ES
dc.contributor.funderNational Eye Institute (US)es_ES
dc.relation.csices_ES
oprm.item.hasRevisionno ko 0 false*
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000780es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003329es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/100000053es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003359es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000781es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/100008666es_ES
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