English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/217978
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

The centrosome protein AKNA regulates neurogenesis via microtubule organization

AuthorsCamargo Ortega, Germán; Falk, Sven; Johansson, Pia A.; Peyre, Elise; Broix, Loïc; Kumar Sahu, Sanjeeb; Hirst, William; Schlichthaerle, Thomas; Juan Romero, Camino de; Draganova, Kalina; Vinopal, Stanislav; Chinnappa, Kaviya; Gavranovic, Anna; Karakaya, Tugay; Steininger, Thomas; Merl-Pham, Juliane; Feederle, Regina; Shao, Wei; Shi, Song-Hai; Hauck, Stefanie M.; Jungmann, Ralf; Bradke, Frank; Borrell, V.; Geerlof, Arie; Reber, Simone; Tiwari, Vijay K.; Huttner, Wieland B.; Wilsch-Bräuninger, Michaela; Nguye, Laurent; Götz, Magdalena
Issue Date2019
PublisherSpringer Nature
CitationNature 567: 113-117 (2019)
AbstractThe expansion of brain size is accompanied by a relative enlargement of the subventricular zone during development. Epithelial-like neural stem cells divide in the ventricular zone at the ventricles of the embryonic brain, self-renew and generate basal progenitors1 that delaminate and settle in the subventricular zone in enlarged brain regions2. The length of time that cells stay in the subventricular zone is essential for controlling further amplification and fate determination. Here we show that the interphase centrosome protein AKNA has a key role in this process. AKNA localizes at the subdistal appendages of the mother centriole in specific subtypes of neural stem cells, and in almost all basal progenitors. This protein is necessary and sufficient to organize centrosomal microtubules, and promote their nucleation and growth. These features of AKNA are important for mediating the delamination process in the formation of the subventricular zone. Moreover, AKNA regulates the exit from the subventricular zone, which reveals the pivotal role of centrosomal microtubule organization in enabling cells to both enter and remain in the subventricular zone. The epithelial-to-mesenchymal transition is also regulated by AKNA in other epithelial cells, demonstrating its general importance for the control of cell delamination.
Publisher version (URL)https://doi.org/10.1038/s41586-019-0962-4
URIhttp://hdl.handle.net/10261/217978
DOI10.1038/s41586-019-0962-4
ISSN0028-0836
E-ISSN1476-4687
Appears in Collections:(IN) Artículos
Files in This Item:
File Description SizeFormat 
precentrosome.pdf5,62 MBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.