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Neurological Disorders in Central Spain, Second Survey: Feasibility Pilot Observational Study

AuthorsHernández-Gallego, Jesús; Llamas-Velasco, Sara; Bermejo-Pareja, Felix; Vega, Saturio; Tapias-Merino, Ester; Rodríguez-Sánchez, Emiliano; Boycheva, Elina; González-Serrano, José Ignacio ; Gil-García, Juan-Francisco; Trincado, Rocío; Vizcaino Sánchez-Rodrigo, José-María; Cacho, Jesús; Contador, Israel; Garcia-Ptacek, Sara; Sierra-Hidalgo, Fernando; Cubo, Esther; Carro, Eva; Villarejo-Galende, Alberto; García García-Patino, Rosalía; Benito-León, Julián
Parkinson’s disease
Essential tremor
Longitudinal study
Issue Date10-Jan-2019
PublisherJournal of Medical Internet Research
CitationJournal of Medical Internet Research 8 (1): e10941 (2019)
AbstractBackground The Neurological Disorders in Central Spain, second survey (NEDICES-2) is a population-based, closed-cohort study that will include over 8000 subjects aged ≥55 years. It will also include a biobank. Objective The objective of this study was to evaluate all major aspects of the NEDICES-2 (methods, database, screening instruments, and questionnaires, as well as interexpert rating of the neurological diagnoses) in each one of the planned areas (all of them in central Spain) and to test the possibility of obtaining biological samples from each participant. Methods A selection of patients and participants of the planned NEDICES-2 underwent face-to-face interviews including a comprehensive questionnaire on demographics, current medications, medical conditions, and lifestyle habits. Biological samples (blood, saliva, urine, and hair) were also obtained. Furthermore, every participant was examined by a neurologist. Results In this pilot study, 567 study participants were enrolled (196 from hospitals and 371 from primary care physician lists). Of these 567, 310 completed all study procedures (questionnaires and the neurological evaluation). The study was time-consuming for several primary care physicians. Hence, a few primary care physicians from some areas refused to participate, which led to a reconfiguration of study areas. In addition, the central biobank needed to be supplemented by the biobanks of local Spanish National Health System hospitals. Conclusions Population-based epidemiological surveys, such as the NEDICES-2, require a pilot study to evaluate the feasibility of all aspects of a future field study (population selection, methods and instruments to be used, neurological diagnosis agreement, and data collection).
Publisher version (URL)http://dx.doi.org/10.2196/10941
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