English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/217929
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:

Title

Notch and EGFR regulate apoptosis in progenitor cells to ensure gut homeostasis in Drosophila

AuthorsReiff, Tobias; Antonello, Zeus A.; Ballesta-Illan, Esther; Mira, Laura; Sala, Salvador; Navarro, Maria; Martínez, Luis M. ; Domínguez, María
KeywordsCaspase
Intestinal enteroblast
Klumpfuss/WT1
Lozenge/RUNX
Issue Date2019
PublisherEMBO Press
CitationEMBO Journal 38(21): e101346 (2019)
AbstractThe regenerative activity of adult stem cells carries a risk of cancer, particularly in highly renewable tissues. Members of the family of inhibitor of apoptosis proteins (IAP s) inhibit caspases and cell death, and are often deregulated in adult cancers; however, their roles in normal adult tissue homeostasis are unclear. Here, we show that regulation of the number of enterocyte‐committed progenitor (enteroblast) cells in the adult Drosophila involves a caspase‐mediated physiological apoptosis, which adaptively eliminates excess enteroblast cells produced by intestinal stem cells (ISC s) and, when blocked, can also lead to tumorigenesis. Importantly, we found that Diap1 is expressed by enteroblast cells and that loss and gain of Diap1 led to changes in enteroblast numbers. We also found that antagonistic interplay between Notch and EGFR signalling governs enteroblast life/death decisions via the Klumpfuss/WT 1 and Lozenge/RUNX transcription regulators, which also regulate enteroblast differentiation and cell fate plasticity. These data provide new insights into how caspases drive adult tissue renewal and protect against the formation of tumours.
Publisher version (URL)https://doi.org/10.15252/embj.2018101346
URIhttp://hdl.handle.net/10261/217929
DOIhttp://dx.doi.org/10.15252/embj.2018101346
ISSN0261-4189
E-ISSN1460-2075
Appears in Collections:(IN) Artículos
Files in This Item:
File Description SizeFormat 
notchegfr.pdf2,45 MBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.