English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/217925
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:

Title

Distinct molecular programs regulate synapse specificity in cortical inhibitory circuits

AuthorsFavuzzi, Emilia; Deogracias, Rubén; Marques-Smith, André; Maeso, Patricia; Jezequel, Julie; Exposito-Alonso, David; Balia, Maddalena; Kroon, Tim; Hinojosa, Antonio J.; Maraver, Elisa F.; Rico, Beatriz
Issue Date2019
PublisherAmerican Association for the Advancement of Science
CitationScience 363(6425): 413-417 (2019)
AbstractHow neuronal connections are established and organized into functional networks determines brain function. In the mammalian cerebral cortex, different classes of GABAergic interneurons exhibit specific connectivity patterns that underlie their ability to shape temporal dynamics and information processing. Much progress has been made toward parsing interneuron diversity, yet the molecular mechanisms by which interneuron-specific connectivity motifs emerge remain unclear. In this study, we investigated transcriptional dynamics in different classes of interneurons during the formation of cortical inhibitory circuits in mouse. We found that whether interneurons form synapses on the dendrites, soma, or axon initial segment of pyramidal cells is determined by synaptic molecules that are expressed in a subtype-specific manner. Thus, cell-specific molecular programs that unfold during early postnatal development underlie the connectivity patterns of cortical interneurons.
URIhttp://hdl.handle.net/10261/217925
DOIhttp://dx.doi.org/10.1126/science.aau8977
ISSN0036-8075
E-ISSN1095-9203
Appears in Collections:(IN) Artículos
Files in This Item:
File Description SizeFormat 
distincircui.pdf21,21 MBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.