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dc.contributor.authorToschi, Nicolaes_ES
dc.contributor.authorArrais Gisbert, Rebecaes_ES
dc.contributor.authorPassamonti, Lucaes_ES
dc.contributor.authorCanals Gamoneda, Santiagoes_ES
dc.contributor.authorSantis, Silvia dees_ES
dc.date.accessioned2020-08-13T10:05:28Z-
dc.date.available2020-08-13T10:05:28Z-
dc.date.issued2020-
dc.identifier.citationNeurobiology of Aging 86: 191-200 (2020)es_ES
dc.identifier.issn0197-4580-
dc.identifier.urihttp://hdl.handle.net/10261/217917-
dc.description.abstractDuring aging, human white matter (WM) is subject to dynamic structural changes which have a deep impact on healthy and pathological evolution of the brain through the lifespan; characterizing this pattern is of key importance for understanding brain development, maturation, and aging as well as for studying its pathological alterations. Diffusion magnetic resonance imaging (MRI) can provide a quantitative assessment of the white-matter microstructural organization that characterizes these trajectories. Here, we use both conventional and advanced diffusion MRI in a cohort of 91 individuals (age range: 13–62 years) to study region- and sex-specific features of WM microstructural integrity in healthy aging. We focus on the age at which microstructural imaging parameters invert their development trend as the time point which marks the onset of microstructural decline in WM. Importantly, our results indicate that age-related brain changes begin earlier in males than females and affect more frontal regions—in accordance with evolutionary theories and numerous evidences across non-MRI domains. Advanced diffusion MRI reveals age-related WM modification patterns which cannot be detected using conventional diffusion tensor imaging.es_ES
dc.description.sponsorshipDr De Santis is supported by a NARSAD Young Investigator Grant (Grant #25104) and by the European Research Council through a Marie Skłodowska-Curie Individual Fellowship. LP is supported by the Medical Research Council, UK (MR/P01271X/1).es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relation.isversionofPostprint-
dc.rightsopenAccesses_ES
dc.subjectAginges_ES
dc.subjectMicrostructural integrityes_ES
dc.subjectDiffusion MRIes_ES
dc.subjectWMes_ES
dc.subjectCHARMEDes_ES
dc.subjectSex differenceses_ES
dc.titleMultishell diffusion imaging reveals sex-specific trajectories of early white matter degeneration in normal aginges_ES
dc.typeartículoes_ES
dc.identifier.doihttp://dx.doi.org/10.1016/j.neurobiolaging.2019.11.014-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttps://doi.org/10.1016/j.neurobiolaging.2019.11.014es_ES
dc.contributor.funderEuropean Commissiones_ES
dc.contributor.funderEuropean Research Counciles_ES
dc.contributor.funderMedical Research Council (UK)es_ES
dc.relation.csices_ES
oprm.item.hasRevisionno ko 0 false*
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000780es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000781es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000265es_ES
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