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Modification of the risk of post-traumatic stress disorder (PTSD) by the 5-HTTLPR polymorphisms after Lorca's earthquakes (Murcia, Spain)

AuthorsNavarro-Mateu, Fernando; Escámez, Teresa; Quesada, Mari Paz; Alcaráz, Mª José; Vilagut, Gemma; Salmerón, Diego; Huerta, José María; Chirlaque, Maria Dolores; Navarro, Carmen; Kessler, Ronald C.; Alonso, Jordi; Martínez, Salvador
Keywords5-HTTLPR polymorphisms
Post-traumatic stress disorder
Gene-environment interaction
Issue Date2019
CitationPsychiatry Research 282: 112640 (2019)
AbstractInformation of the modulation effect of the serotonin transporter gene-linked polymorphic region (5-HTTLPR) on post-traumatic stress disorder (PTSD) after earthquakes is scarce and contradictory. A cross-sectional face-to-face interview survey of a representative sample of the adults was carried out after the Lorca (Spain) earthquakes (May 11, 2011). Socio-demographic variables, DSM-IV diagnostic assessment and earthquake-related stressors were obtained from the Composite International Diagnostic Interview (CIDI). The triallelic and biallelic classification of the 5-HTTLPR polymorphism were genotyped from buccal swabs. Multivariate logistic regression models were used to predict PTSD, including interaction terms to explore gene-environment (G x E) interactions. The vast majority (83%, n = 341) of the Lorca survey respondents (n = 412, 71% response rate) were genotyped. Both classifications of the 5-HTTLPR genotype were in Hardy-Weinberg equilibrium. Prior lifetime PTSD was the only variable that remained a significant predictor after adjustments. There were no significant main effects of earthquake related stressors or 5-HTTLPR. However, G x E interactions of 5-HTTLPR with high emotional impact and prior lifetime anxiety disorders were statistically significant. These results provide new evidence of the modulation effect of the 5-HTTLPR polymorphisms on PTSD risk. This information might characterize people at higher risk of developing PTSD after an earthquake exposure.
DescriptionPreliminary results of this study were presented as a poster at the XVI World Congress of the World Psychiatry in Madrid, Spain, in September 2014; at XIX National Congress of Psychiatry in Palma de Mallorca, in October 2016; and at XVII SESPAS Congress (“Ciencia para la Acción”) in Barcelona, Septembre 2017.
Publisher version (URL)https://doi.org/10.1016/j.psychres.2019.112640
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