English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/217910
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Glyphosate-based herbicides influence antioxidants, reproductive hormones and gut microbiome but not reproduction: A long-term experiment in an avian model

AuthorsRuuskanen, S.; Rainio, M.J.; Gómez-Gallego, Carlos; Selenius, O.; Salminen, S.; Collado, María Carmen ; Saikkonen, K.; Saloniemi, I.; Helander, M.
KeywordsGlyphosate
Herbicide
Residue
Gut microbiome
Endocrine disruption
Oxidative status
Testosterone
Issue Date5-Jul-2020
PublisherElsevier
CitationEnvironmental Pollution 266: 115108 (2020)
AbstractControversial glyphosate-based herbicides (GBHs) are the most frequently used herbicides globally. GBH residues in the wild, in animal and human food may expose non-target organisms to health risks, yet the developmental and cumulative effects of GBHs on physiology and reproduction remain poorly understood. We present the first long-term study on the effects of subtoxic GBH exposure (160 mg/kg) on multiple key physiological biomarkers (cellular oxidative status and neurotransmitters), gut microbiome, reproductive hormones, and reproduction in an avian model. We experimentally exposed in Japanese quail females and males (Coturnix japonica) to GBHs and respective controls from the age of 10 days–52 weeks. GBH exposure decreased hepatic activity of an intracellular antioxidant enzyme (catalase), independent of sex, but did not influence other intracellular oxidative stress biomarkers or neurotransmitter enzyme (acetylcholinesterase). GBH exposure altered overall gut microbiome composition, especially at a younger age and in females, and suppressed potentially beneficial microbes at an early age. Many of the microbial groups increased in frequency from 12 to 28 weeks under GBH exposure. GBH exposure decreased male testosterone levels both at sexual maturity and at 52 weeks of exposure, but did not clearly influence reproduction in either sex (maturation, testis size or egg production). Future studies are needed to characterize the effects on reproductive physiology in more detail. Our results suggest that cumulative GBH exposure may influence health and reproduction-related traits, which is important in predicting their effects on wild populations and global poultry industry.
URIhttp://hdl.handle.net/10261/217910
DOI10.1016/j.envpol.2020.115108
ISSN0269-7491
Appears in Collections:(IATA) Artículos
Files in This Item:
File Description SizeFormat 
Ruuskanen_EnvPol2020.pdfArtículo principal1,42 MBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.