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Measurement of CSF α‐synuclein improves early differential diagnosis of mild cognitive impairment due to Alzheimer’s disease

AuthorsGarcía-Ayllón, María-Salud; Monge‐Argilés, José‐Antonio; Monge‐García, Victoria; Navarrete, Francisco; Cortés‐Gómez, Maria‐Angeles; Sánchez-Payá, José; Manzanares, Jorge; Gasparini‐Berenguer, Ruth; Leiva-Santana, Carlos; Sáez-Valero, Javier
Lewy body disease
Mild cognitive impairment
Issue Date2019
PublisherJohn Wiley & Sons
CitationJournal of Neurochemistry 150(2): 218-230 (2019)
AbstractPrevious studies have indicated the potential of cerebrospinal fluid (CSF) α‐synuclein (α‐syn) to be an additional biomarker for improving differential diagnosis of Alzheimer’s disease (AD). We evaluated α‐syn diagnostic performance across a well‐characterized patient cohort with long‐term follow‐up. For this purpose, CSF α‐syn levels were determined in 25 subjects diagnosed with stable mild cognitive impairment (stable MCI; n = 25), 27 MCI cases due to AD (MCI‐AD; n = 32), 24 MCI cases due to Lewy body disease (MCI‐LBD; n = 24) and control subjects (Ctrl; n = 18). CSF α‐syn levels discriminate between the four groups. There were higher α‐syn levels in MCI‐AD patients and lower levels in MCI‐LBD patients. The combination of α‐syn and P‐tau resulted in a specificity of 99% and a sensitivity of 97% for MCI‐AD. MCI‐AD patients with early psychotic symptoms (n = 9) displayed a trend towards a decrease in P‐tau and α‐syn compared to the MCI‐AD patients without psychotic symptoms (n = 23). We conclude that adding CSF α‐syn to central core AD biomarkers improves an early differential diagnosis of MCI‐AD from other forms of MCI.
Publisher version (URL)https://doi.org/10.1111/jnc.14719
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