English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/217856
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:

Title

Incubation of neural alcohol cue reactivity after withdrawal and its blockade by naltrexone

AuthorsBach, Patrick; Weil, Georg; Pompili, Enrico; Hoffmann, Sabine; Hermann, Derik; Vollstädt‐Klein, Sabine; Mann, Karl; Pérez-Ramírez, Úrsula; Moratal, David; Canals Gamoneda, Santiago; Dursun, Serdar M.; Greenshaw, Andrew J.; Kirsch, Peter; Kiefer, Falk; Sommer, Wolfgang H.
Issue Date2019
PublisherJohn Wiley & Sons
CitationAddiction Biology 25(1): e12717 (2019)
AbstractDuring the first weeks of abstinence, alcohol craving in patients may increase or “incubate.” We hypothesize that Naltrexone (NTX) blocks this incubation effect. Here, we compared NTX effects on neural alcohol cue reactivity (CR) over the first weeks of abstinence and on long‐term clinical outcomes to standard treatment. Male alcohol‐dependent patients (n = 55) and healthy controls (n = 35) were enrolled. Participants underwent baseline psychometric testing and functional magnetic resonance imaging (fMRI) assessment of mesolimbic alcohol CR. Patients participated in a standard treatment program with the option of adjuvant NTX. They received another scan after 2 weeks of treatment. We found higher CR in several brain regions in patients versus healthy controls. CR significantly increased over 2 weeks in the standard treatment group (n = 13) but not in the NTX group (n = 22). NTX significantly attenuated CR in the left putamen and reduced relapse risk to heavy drinking within 3 months of treatment. Additionally, increased CR in the left putamen and its course over time predicted both NTX response and relapse risk. Carrier status for the functional OPRM1 variant rs1799971:A > G was considered but had no effect on NTX efficacy. In conclusion, NTX was most effective in patients with high CR in the left putamen. While the results from our naturalistic study await further confirmation from prospective randomized trials, they support a potential role of neural CR as a biomarker in the development of precision medicine approaches with NTX.
Publisher version (URL)https://doi.org/10.1111/adb.12717
URIhttp://hdl.handle.net/10261/217856
DOIhttp://dx.doi.org/10.1111/adb.12717
ISSN1355-6215
E-ISSN1369-1600
Appears in Collections:(IN) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf59,24 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.