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Title

Adaptation to iron deficiency in human pathogenic fungi

AuthorsMartínez-Pastor, M.Teresa; Puig, Sergi
KeywordsFungi
Yeast
Iron deficiency
Iron transport
Iron metabolism
Transcriptional regulation
Virulence
Issue Date11-Jul-2020
CitationBiochimica et Biophysica Acta - Molecular Cell Research 1867 (10): 118797 (2020)
AbstractIron is an essential micronutrient for virtually all eukaryotic organisms and plays a central role during microbial infections. Invasive fungal diseases are associated with strikingly high rates of mortality, but their impact on human health is usually underestimated. Upon a fungal infection, hosts restrict iron availability in order to limit the growth and virulence of the pathogen. Here, we use two model yeasts, Saccharomyces cerevisiae and Schizosaccharomyces pombe, to delve into the response to iron deficiency of human fungal pathogens, such as Candida glabrata, Candida albicans, Aspergillus fumigatus and Cryptococcus neoformans. Fungi possess common and species-specific mechanisms to acquire iron and to control the response to iron limitation. Upon iron scarcity, fungi activate a wide range of elegant strategies to capture and import exogenous iron, mobilize iron from intracellular stores, and modulate their metabolism to economize and prioritize iron utilization. Hence, iron homeostasis genes represent remarkable virulence factors that can be used as targets for the development of novel antifungal treatments.
Publisher version (URL)https://doi.org/10.1016/j.bbamcr.2020.118797
URIhttp://hdl.handle.net/10261/217828
DOI10.1016/j.bbamcr.2020.118797
ISSN0167-4889
Appears in Collections:(IATA) Artículos
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