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Title

Eph signaling controls mitotic spindle orientation and cell proliferation in neuroepithelial cells

AuthorsFranco, Maribel; Carmena, Ana
Issue Date2019
PublisherRockefeller University Press
CitationJournal of Cell Biology 218(4): 1200–1217 (2019)
AbstractMitotic spindle orientation must be tightly regulated during development and adult tissue homeostasis. It determines cell-fate specification and tissue architecture during asymmetric and symmetric cell division, respectively. Here, we uncover a novel role for Ephrin–Eph intercellular signaling in controlling mitotic spindle alignment in Drosophila optic lobe neuroepithelial cells through aPKC activity–dependent myosin II regulation. We show that conserved core components of the mitotic spindle orientation machinery, including Discs Large1, Mud/NuMA, and Canoe/Afadin, mislocalize in dividing Eph mutant neuroepithelial cells and produce spindle alignment defects in these cells when they are down-regulated. In addition, the loss of Eph leads to a Rho signaling–dependent activation of the PI3K–Akt1 pathway, enhancing cell proliferation within this neuroepithelium. Hence, Eph signaling is a novel extrinsic mechanism that regulates both spindle orientation and cell proliferation in the Drosophila optic lobe neuroepithelium. Similar mechanisms could operate in other Drosophila and vertebrate epithelia.
Publisher version (URL)https://doi.org/10.1083/jcb.201807157
URIhttp://hdl.handle.net/10261/217817
DOIhttp://dx.doi.org/10.1083/jcb.201807157
ISSN0021-9525
E-ISSN1540-8140
Appears in Collections:(IN) Artículos
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